Document Detail

Resveratrol Modulates the Angiogenic Response to Exercise Training in Skeletal Muscle of Aged Men.
MedLine Citation:
PMID:  25128170     Owner:  NLM     Status:  Publisher    
Aim: The polyphenol resveratrol has in animal studies been shown to influence several pathways of importance for angiogenesis in skeletal muscle. The aim was to examine the angiogenic effect of resveratrol supplementation with parallel exercise training in aged men. Methods: Forty-three healthy physically inactive aged men (65±1 years) were divided into A) a training group that conducted 8 weeks of intense exercise training where half of the subjects received a daily intake of either 250 mg trans resveratrol (n=14) and the other half received placebo (n=13); and B) a non-training group that received either 250 mg trans resveratrol (n=9) or placebo (n=7). Results: The group that trained with placebo showed a ~20% increase in capillary to fiber (C:F) ratio, an increase in the muscle protein expression of vascular endothelial growth factor (VEGF), VEGF receptor-2, and tissue inhibitor of matrix metalloproteinase (TIMP-1) but unaltered thrombospodin-1 (TSP-1) levels. Muscle interstitial VEGF and TSP-1 protein levels were unchanged after the training period. The group training with resveratrol supplementation did not show an increase in C:F ratio or an increase in muscle VEGF protein. Muscle TIMP-1 protein levels were lower in the training and resveratrol group than in the training and placebo group. Both training groups showed an increase in Forkhead box O1 protein. In the non-training groups, TIMP-1 protein was lower in the resveratrol group than the placebo group after 8 weeks. Conclusion: These data show that exercise training has a strong angiogenic effect whereas resveratrol supplementation may limit basal and training-induced angiogenesis.
Lasse Gliemann; Jesper Olesen; Rasmus S Biensø; Jakob Schmidt; Thorbjorn Akerstrom; Michael Nyberg; Anna Lindqvist; Jens Bangsbo; Ylva Hellsten
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-15
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Heart and Circulatory Physiology.
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