| Resveratrol (3,5,4'-trihydroxystilbene) protects pregnant mother and fetus from the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. | |
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MedLine Citation:
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PMID: 20715097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SCOPE: The "fetal basis of adult disease" hypothesis proposes that prenatal exposure to environmental stress can lead to increased susceptibility to clinical disorders later in life. In utero exposure of fetus to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to alterations in T-cell differentiation in the thymus and increased susceptibility to autoimmune disease later in life. TCDD triggers toxicity through activation of aryl hydrocarbon receptor and severely affects maternal and fetal immune system during pregnancy. METHODS AND RESULTS: In this study, using a mouse model, we investigated if administration of resveratrol (RES; 3,5,4'-trihydroxystilbene) would inhibit immunotoxicity induced by TCDD during pregnancy in the mother and fetus. We observed that RES protected not only normal nonpregnant mice but also pregnant mothers and their fetuses from TCDD-induced thymic atrophy, apoptosis, and alterations in the expression of T-cell receptor and costimulatory molecules as well as T-cell differentiation. In addition, there was significantly reduced expression of CYP1A1 in thymi of both the mother and the fetus when RES was used in vivo post-TCDD exposure. CONCLUSION: In conclusion, these studies demonstrate that consumption of RES, a natural plant product, during pregnancy, may afford protection to the mother and the fetus from the toxicity induced by environmental pollutants that mediate their effects through activation of aryl hydrocarbon receptor. |
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Authors:
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Narendra P Singh; Ugra S Singh; Mitzi Nagarkatti; Prakash S Nagarkatti |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-16 |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 55 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-03 Completed Date: 2011-05-26 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 209-19 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Columbia, SC 29208, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Atrophy / prevention & control Cell Differentiation / drug effects Cells, Cultured Cytochrome P-450 CYP1A1 / genetics, metabolism Environmental Pollutants / toxicity* Female Fetus / drug effects*, immunology, metabolism, pathology Gene Expression Regulation / drug effects Maternal Exposure / adverse effects Mice Mice, Inbred C57BL Pregnancy Protective Agents / pharmacology, therapeutic use* Receptors, Aryl Hydrocarbon / antagonists & inhibitors Stilbenes / pharmacology, therapeutic use* T-Lymphocyte Subsets / drug effects, metabolism Tetrachlorodibenzodioxin / toxicity* Thymus Gland / drug effects*, immunology, metabolism, pathology |
| Grant Support | |
ID/Acronym/Agency:
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P01 AT003961-01A1/AT/NCCAM NIH HHS; P01-AT03961/AT/NCCAM NIH HHS; R01 DA016545-01/DA/NIDA NIH HHS; R01 ES009098-06A1/ES/NIEHS NIH HHS; R01 ES019313-03/ES/NIEHS NIH HHS; R01-DA016545/DA/NIDA NIH HHS; R01-ES09098/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Protective Agents; 0/Receptors, Aryl Hydrocarbon; 0/Stilbenes; 1746-01-6/Tetrachlorodibenzodioxin; 501-36-0/resveratrol; EC 1.14.14.1/Cytochrome P-450 CYP1A1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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