Document Detail


Resuscitation with polymerized human placenta hemoglobin attenuated hemorrhagic shock-induced lung injury.
MedLine Citation:
PMID:  22947048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to investigate whether polymerized human placenta hemoglobin (PolyPHb) attenuated hemorrhagic shock-induced lung injury. A mean arterial pressure (MAP) of 30mmHg was maintained for 60 min. Then, all the rats were randomly resuscitated with hetastarch, whole blood, or PolyPHb. The result indicated that PolyPHb greatly improved the MAP and pulmonary function, and significantly reduced the release of inflammatory cytokines, histopathological changes, and pulmonary edema. Therefore, our findings suggest that PolyPHb could reduce pulmonary injury after hemorrhagic shock, and this effect was probably associated with the depressed inflammatory response.
Authors:
Tao Li; Zhenyu Zhang; Wei Wu; Daqin Liao; Yanfang Chen; Shen Li; Chengmin Yang; Xuewen Xu; Jin Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-04
Journal Detail:
Title:  Artificial cells, nanomedicine, and biotechnology     Volume:  41     ISSN:  2169-141X     ISO Abbreviation:  Artif Cells Nanomed Biotechnol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-07-23     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101594777     Medline TA:  Artif Cells Nanomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Pressure / drug effects
Cytokines / metabolism
Female
Hemoglobins / administration & dosage*,  chemical synthesis,  metabolism
Humans
Inflammation Mediators / metabolism
Lung / drug effects*,  immunology,  pathology
Lung Injury / etiology,  immunology,  prevention & control*
Male
Placenta / metabolism
Polymerization
Pregnancy
Pulmonary Edema / etiology,  immunology,  prevention & control*
Rats
Rats, Sprague-Dawley
Respiratory Function Tests
Resuscitation*
Shock, Hemorrhagic / complications,  drug therapy*,  immunology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Hemoglobins; 0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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