| Resuscitation with 21 or 100% oxygen in hypoxic nicotine-pretreated newborn piglets: possible neuroprotective effects of nicotine. | |
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MedLine Citation:
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PMID: 17630496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Perinatal asphyxia is a major concern in perinatal medicine. Resuscitation and ways to prevent and minimize adverse outcomes after perinatal asphyxia are subject to extensive research. OBJECTIVES: In this study we hypothesized that, prior to hypoxia, intravenously administered nicotine might have an effect on how newborn piglets tolerate hypoxia, with regard to the time and degree of damage inflicted, due to its suggested neuroprotective abilities, and further that resuscitation with 21 compared with 100% oxygen in nicotine-pretreated animals would cause less cerebral damage. METHODS: Thirty anesthetized newborn piglets were randomized to either hypoxia or control groups, and pretreatment with either saline or nicotine. In addition, the nicotine/hypoxia group was randomized to resuscitation with either 21 or 100% oxygen for 15 min following hypoxia. RESULTS: We found significantly more necrosis in the striatum and cortex combined (p = 0.036), and in the striatum alone (p = 0.026), in the animals pretreated with nicotine and resuscitated with 100% when compared to 21% oxygen. There was no significant difference in the cerebellum. We also found significantly increased tolerance to hypoxia as measured by the time interval that the animals endured hypoxia: 103.8 +/- 28.2 min in the nicotine-pretreated animals vs. 66.5 +/- 19.5 min in the saline-pretreated animals (p = 0.035). CONCLUSION: Nicotine enhances newborn piglets' ability to endure hypoxia, and resuscitation with 21% oxygen inflicts less necrosis than 100% oxygen. The potential neuroprotective effects of nicotine in the newborn brain should be further investigated. |
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Authors:
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Jannicke H Andresen; Rønnaug Solberg; Else Marit Løberg; Berit H Munkeby; Babill Stray-Pedersen; Ola Didrik Saugstad |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-12 |
Journal Detail:
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Title: Neonatology Volume: 93 ISSN: 1661-7819 ISO Abbreviation: - Publication Date: 2008 |
Date Detail:
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Created Date: 2007-12-18 Completed Date: 2008-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 36-44 Citation Subset: IM |
Copyright Information:
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(c) 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Pediatric Research, Medical Faculty, University of Oslo, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway. j.h.andresen@medisin.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cerebral Cortex / pathology Corpus Striatum / pathology Female Humans Hypoxia, Brain / pathology, therapy* Male Models, Animal Neuroprotective Agents / therapeutic use* Nicotine / therapeutic use* Nicotinic Agonists / therapeutic use* Oxygen Inhalation Therapy / methods* Resuscitation / methods* Swine |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 0/Nicotinic Agonists; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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