Document Detail

Resuscitation outcomes comparing year 2000 with year 2005 ALS guidelines in a pig model of cardiac arrest.
MedLine Citation:
PMID:  17291669     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ventricular fibrillation remains the leading cause of death in western societies. International organizations publish guidelines to follow in case of cardiac arrest. The aim of the present study is to assess whether the newly published guidelines record similar resuscitation success with the 2000 Advanced Life Support Guidelines on Resuscitation in a swine model of cardiac arrest. METHODS AND RESULTS: Nineteen landrace/large white pigs were used. Ventricular fibrillation was induced with the use of a transvenous pacing wire inserted into the right ventricle. The animals were randomized into two groups. In Group A, 10 animals were resuscitated using the 2000 guidelines, whereas in Group B, 9 animals were resuscitated using the 2005 guidelines. Both algorithms recorded similar successful resuscitation rates, as 60% of the animals in Group A and 44.5% in Group B were successfully resuscitated. However, animals in Group A restored a rhythm, compatible with a pulse, quicker than those in Group B (p=0.002). Coronary perfusion pressure (CPP) was not adversely affected by three defibrillation attempts in Group A. CONCLUSIONS: Both algorithms' resulted in comparable resuscitation success, however, guidelines 2000 resulted in faster resuscitation times. These preliminary results merit further investigation.
Theodoros Xanthos; Nikolas Tsirikos-Karapanos; Dimitrios Papadimitriou; Ioannis S Vlachos; Katerina Tsiftsi; Konstantinos A Ekmektzoglou; Lila Papadimitriou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-08
Journal Detail:
Title:  Resuscitation     Volume:  73     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-08-17     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  459-66     Citation Subset:  IM    
Department of Experimental Surgery and Surgical Research N.S.Christeas, Athens School of Medicine, 15B Agiou Thoma Street, 11527 Athens, Greece.
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MeSH Terms
Advanced Cardiac Life Support / methods,  standards*
Heart Arrest / therapy*
Practice Guidelines as Topic
Treatment Outcome

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