| Resuscitation-induced intestinal edema decreases the stiffness and residual stress of the intestine. | |
| | |
MedLine Citation:
|
PMID: 16044088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have shown that acute edema impairs intestinal transit and we wanted to know whether this could be from changes in the physical characteristics of the intestine. Our hypothesis was that acute edema will change the physical characteristics of the intestine, which were measured by standardized engineering measures of elastic modulus, to determine stiffness and opening angle, and to determine residual stress. Rats were randomized to sham, mild edema (80 mL/ kg of normal saline resuscitation), and severe edema groups (80 mL/kg of normal saline resuscitation with intestinal venous hypertension). Segments of distal ileum were hung to a fixed point in a tissue bath and to a tensiometer and were stretched in increments of 1 mm, recording the new length and the corresponding force from the tensiometer to determine elastic modulus. Next, two transverse cuts were made yielding a 1- to 2-mm-thick ring-shaped segment of tissue and were then cut radially to open the ring. The opening angle was measured. Acute intestinal edema led to a decrease in transit, elastic modulus, and opening angle of the intestine in the absence of ischemic injury. Acute intestinal edema leads to a significant loss in stiffness and residual stress and is a plausible explanation for how acute edema impairs intestinal transit. |
| | |
Authors:
|
Ravi S Radhakrishnan; Hasan Xue; Norman Weisbrodt; Frederick A Moore; Steven J Allen; Glenn A Laine; Charles S Cox |
Related Documents
:
|
11124758 - Small-bowel absorption of d-tagatose and related effects on carbohydrate digestibility:... 10450558 - Secretion and excretion of immunoglobulin a to cecum and feces differ with type of indi... 8536508 - Morphometric analysis of intestinal mucins under different dietary conditions and gut f... 6423798 - Effect of casein versus casein hydrolysate on mucosal adaptation following massive bowe... 3946288 - Dietary carnitine intake related to skeletal muscle and plasma carnitine concentrations... 17158428 - Vitamin e: maternal concentrations are associated with fetal growth. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Shock (Augusta, Ga.) Volume: 24 ISSN: 1073-2322 ISO Abbreviation: Shock Publication Date: 2005 Aug |
Date Detail:
|
Created Date: 2005-07-26 Completed Date: 2005-11-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9421564 Medline TA: Shock Country: United States |
Other Details:
|
Languages: eng Pagination: 165-70 Citation Subset: IM |
Affiliation:
|
Department of Surgery, University of Texas, Houston Medical School, 77030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Edema / pathology* Ileum / pathology Intestines / injuries, metabolism, pathology* Lactates / metabolism Male Models, Biological Oxygen / metabolism Rats Rats, Sprague-Dawley Resuscitation / methods* Shock, Hemorrhagic / pathology Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
|
5KO8 GM00675/GM/NIGMS NIH HHS; CCU-620069/CC/CDC HHS; P50 GM38529/GM/NIGMS NIH HHS; R01 HL36115/HL/NHLBI NIH HHS; T32 GM08792/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Moderate hypothermia protects against systemic oxidative stress in a rat model of intestinal ischemi...
Next Document: Peritoneal lavage with oxygenated perfluorochemical improves hemodynamics, intestinal injury, and su...