| Resuscitation of hemorrhage with intraosseous infusion of hypertonic saline/dextran. | |
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MedLine Citation:
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PMID: 2477095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We resuscitated unanesthetized bled sheep (bled volume = 1.2-1.7 liters) with 200 ml of hypertonic saline/dextran 70 infused either through a peripheral vein (n = 6) or directly into the red marrow of the sternum (n = 6). Intraosseous infusion of the viscous 7.5% NaCl/6% dextran solution required 2-4 min. Plasma sodium was rapidly increased to the same level in both groups demonstrating equally rapid entry into the vascular space. Both regimens provide rapid and sustained normalization of arterial pressure and cardiac output. No significant differences between the two groups were apparent for any measured variable. Intraosseous infusion of hypertonic resuscitation fluids merits further research to evaluate the safety and efficacy for prehospital treatment of hypovolemia and trauma. |
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Authors:
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G C Kramer; J C Walsh; R D Hands; P R Perron; R A Gunther; S Mertens; J W Holcroft; F W Blaisdell |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 22 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-17 Completed Date: 1989-11-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 283-6 Citation Subset: IM |
Affiliation:
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Department of Human Physiology, School of Medicine, University of California, Davis 95616. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dextrans Fluid Therapy / methods* Hemodynamics / drug effects Infusions, Intravenous Injections, Spinal Resuscitation* Saline Solution, Hypertonic Sheep Shock / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Saline Solution, Hypertonic; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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