| Resuscitation-Promoting Factors (RPF): In Search of Inhibitors. | |
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MedLine Citation:
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PMID: 22533619 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity. |
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Authors:
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Arseny S Kaprelyants; Galina V Mukamolova; Alessia Ruggiero; Vadim A Makarov; Galina R Demina; Margarita O Shleeva; Vasilii D Potapov; Pavel A Shramko |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-25 |
Journal Detail:
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Title: Protein and peptide letters Volume: - ISSN: 1875-5305 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441434 Medline TA: Protein Pept Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Leninsky pr.33, 119071, Moscow, Russia. arseny@inbi.ras.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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