Document Detail

Resurgence of cases of epileptic seizures and burns associated with cysticercosis in Assologaima, Jayawijaya, Irian Jaya, Indonesia, 1991-95.
MedLine Citation:
PMID:  10748897     Owner:  NLM     Status:  MEDLINE    
Historically, neurocysticercosis (NCC) caused by the larval stage, cysticercus or cysticerci, of the pork tapeworm Taenia solium was recognized in Paniai District, western Irian Jaya Province, Indonesia, in the early 1970s. In the 1990s, we observed a rapid increase in the number of cases of epileptic seizures and burns in Assologaima Sub-District, Jayawijaya District, eastern Irian Jaya. There were totals of 1120 new cases of burns and 293 new cases of epileptic seizures during 1991-95 in Assologaima where the number of inhabitants was 15,939. Histopathological examination of resected cysts from patients and a pig revealed that they were cysticerci of T. solium. DNA analysis of these cysts revealed that the nucleotide sequences of 391 base-pair fragments of the mitochondrial cytochrome c oxidase subunit 1 gene were exactly the same in those from patients and the pig. Although 3 of 391 base-pair fragments might differ from that of T. solium reported previously, there were no differences in the amino-acid sequences. Approximately 67% and 65% of persons with epileptic seizures and with subcutaneous nodules, respectively, showed antibody responses highly specific to cysticercosis. Therefore, most cases of epileptic seizures and burns were considered to be associated with cysticercosis in Irian Jaya.
T Wandra; R Subahar; G M Simanjuntak; S S Margono; T Suroso; M Okamoto; M Nakao; Y Sako; K Nakaya; P M Schantz; A Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  94     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-04-26     Completed Date:  2000-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Ministry of Health, Jakarta, Indonesia.
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MeSH Terms
Age Distribution
Aged, 80 and over
Burns / epidemiology*
Child, Preschool
Disease Reservoirs*
Epilepsy / epidemiology*,  pathology
Genes, Helminth
Indonesia / epidemiology
Middle Aged
Neurocysticercosis / diagnosis,  epidemiology*,  transmission
Serologic Tests
Taenia / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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