| Resumption of HIV replication is associated with monocyte/macrophage derived cytokine and chemokine changes: results from a large international clinical trial. | |
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MedLine Citation:
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PMID: 21505304 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:: There is increasing interest in the role of immune activation and inflammation in HIV disease, but data on direct effects of HIV replication on immune cell activation are limited. METHODS:: High sensitivity multiplex bead array assays (MBAAs) were used to measure changes in plasma cytokines and chemokines [interleukin (IL)-1β, IL-2, IL-6, IL-7, IL-8, IL-12p70, IL-17, tumor necrosis factor-α (TNFα), interferon-γ, granulocyte macrophage colony-stimulating factor, IL-4, IL-5, IL-10, IL-13, CXCL10] from randomization (month 0) to month 2 in a random sample of 200 patients from both the drug conservation (DC) and viral suppression (VS) arms of the Strategies for Management of Antiretroviral Therapy (SMART) trial. IL-6 was also measured by ELISA. Data were evaluated using nonparametric correlation and censored parametric analysis of covariance and associations were declared as statistically significant when the Bonferroni-adjusted P-value was less than 0.003. RESULTS:: Compared with the VS arm, significant increases were seen in the DC arm for TNFα (+0.34 loge pg/ml, P = 0.0001), IL-10 (+0.31 loge pg/ml, P = 0.00001) and CXCL10 (+0.66 loge pg/ml, P = 0.00001). IL-6 ELISA poorly correlated with IL-6 MBAA (Spearman's rho = 0.29, P = 0.0001). CONCLUSION:: Resumption of HIV replication after ceasing antiretroviral therapy is associated predominantly with an increase of monocyte/macrophage-derived cytokines. Measurement of IL-6 levels may be affected by assay method and this should be considered in future studies of biomarkers. |
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Authors:
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Alessandro Cozzi-Lepri; Martyn A French; John Baxter; Pablo Okhuysen; Montserrat Plana; Jacqueline Neuhaus; Alan Landay; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-18 |
Journal Detail:
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Title: AIDS (London, England) Volume: - ISSN: 1473-5571 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aResearch Department of Infection and Population Health, Royal Free Campus, University College London, London, UK bDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA cSchool of Pathology and Laboratory Medicine, University of Western Australia dDepartment of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Western Australia, Australia eCooper University Hospital/UMDNJ-Robert Wood Johnson Medical School, Camden, New Jersey, USA fDivision of Infectious Diseases, UT Health Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA gHospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain hDepartment of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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