Document Detail


Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy.
MedLine Citation:
PMID:  7837013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy. Twenty-two patients received injections and 25 acted as controls. The overall etiologies were microvascular (72.3%), unknown (17%), multiple sclerosis (6%), and one case each of central nervous system (CNS) sarcoidosis and basilar artery ectasia. Eighty-three percent of the patients entered the trial within 2 weeks of the onset of symptoms and 95.7% within 3 weeks. The controls had a final recovery rate of 20/25 (80%), and the injected group had a final recovery rate of 19/22 (86%). No serious side effects were encountered. We conclude that there is no evidence for a prophylactic effect of botulinum toxin in the group that we have studied.
Authors:
J Lee; S Harris; J Cohen; K Cooper; C MacEwen; S Jones
Related Documents :
16336883 - Single-center, double-blind, randomized study to evaluate the efficacy of 4% lidocaine ...
3032603 - The prophylactic use of polyvinylpyridine-n-oxide (pvno) in baboons exposed to quartz d...
22144923 - Maternal and neonatal effects of nalbuphine given immediately before induction of gener...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  31     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  IM    
Affiliation:
Botulinum Toxin Clinic, Moorfields Eye Hospital, London, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abducens Nerve*
Acute Disease
Adult
Aged
Aged, 80 and over
Botulinum Toxins / therapeutic use*
Cranial Nerve Diseases / drug therapy
Eye Movements
Female
Follow-Up Studies
Humans
Injections
Male
Middle Aged
Paralysis / drug therapy*
Prognosis
Prospective Studies
Vision, Binocular
Chemical
Reg. No./Substance:
0/Botulinum Toxins
Comments/Corrections
Comment In:
J Pediatr Ophthalmol Strabismus. 1995 May-Jun;32(3):142   [PMID:  7636691 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Progress toward Healthy People 2000: a preliminary look at Oklahoma.
Next Document:  The use of hyaluronic acid during adjustable suture surgery.