Document Detail

Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy.
MedLine Citation:
PMID:  7837013     Owner:  NLM     Status:  MEDLINE    
Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy. Twenty-two patients received injections and 25 acted as controls. The overall etiologies were microvascular (72.3%), unknown (17%), multiple sclerosis (6%), and one case each of central nervous system (CNS) sarcoidosis and basilar artery ectasia. Eighty-three percent of the patients entered the trial within 2 weeks of the onset of symptoms and 95.7% within 3 weeks. The controls had a final recovery rate of 20/25 (80%), and the injected group had a final recovery rate of 19/22 (86%). No serious side effects were encountered. We conclude that there is no evidence for a prophylactic effect of botulinum toxin in the group that we have studied.
J Lee; S Harris; J Cohen; K Cooper; C MacEwen; S Jones
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  31     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  IM    
Botulinum Toxin Clinic, Moorfields Eye Hospital, London, England.
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MeSH Terms
Abducens Nerve*
Acute Disease
Aged, 80 and over
Botulinum Toxins / therapeutic use*
Cranial Nerve Diseases / drug therapy
Eye Movements
Follow-Up Studies
Middle Aged
Paralysis / drug therapy*
Prospective Studies
Vision, Binocular
Reg. No./Substance:
0/Botulinum Toxins
Comment In:
J Pediatr Ophthalmol Strabismus. 1995 May-Jun;32(3):142   [PMID:  7636691 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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