| Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy. | |
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MedLine Citation:
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PMID: 7837013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy. Twenty-two patients received injections and 25 acted as controls. The overall etiologies were microvascular (72.3%), unknown (17%), multiple sclerosis (6%), and one case each of central nervous system (CNS) sarcoidosis and basilar artery ectasia. Eighty-three percent of the patients entered the trial within 2 weeks of the onset of symptoms and 95.7% within 3 weeks. The controls had a final recovery rate of 20/25 (80%), and the injected group had a final recovery rate of 19/22 (86%). No serious side effects were encountered. We conclude that there is no evidence for a prophylactic effect of botulinum toxin in the group that we have studied. |
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Authors:
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J Lee; S Harris; J Cohen; K Cooper; C MacEwen; S Jones |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of pediatric ophthalmology and strabismus Volume: 31 ISSN: 0191-3913 ISO Abbreviation: J Pediatr Ophthalmol Strabismus Publication Date: 1994 Sep-Oct |
Date Detail:
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Created Date: 1995-03-02 Completed Date: 1995-03-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7901143 Medline TA: J Pediatr Ophthalmol Strabismus Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-6 Citation Subset: IM |
Affiliation:
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Botulinum Toxin Clinic, Moorfields Eye Hospital, London, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abducens Nerve* Acute Disease Adult Aged Aged, 80 and over Botulinum Toxins / therapeutic use* Cranial Nerve Diseases / drug therapy Eye Movements Female Follow-Up Studies Humans Injections Male Middle Aged Paralysis / drug therapy* Prognosis Prospective Studies Vision, Binocular |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxins |
| Comments/Corrections | |
Comment In:
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J Pediatr Ophthalmol Strabismus. 1995 May-Jun;32(3):142
[PMID:
7636691
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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