Document Detail


Results of the primary treatment in T1-3M0 prostatic adenocarcinoma are dependent on tumour biology.
MedLine Citation:
PMID:  7763039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of the primary treatment were analysed in relation to biological prognostic factors in a series of 215 males with T1-3M0 prostatic adenocarcinoma. T-category, Gleason score and DNA ploidy were significantly related to progression-free survival and overall survival. Incidental tumours usually had a favorable prognosis, 86% of them being diploid, whereas the incidental aneuploid tumours (14%) ran an unfavorable course. In clinically malignant prostates (TPR), neither Gleason score nor DNA ploidy had prognostic significance. The treatment had prognostic significance only in diploid tumours or in tumours with Gleason score value < or = 7, while aneuploid tumours or tumours with Gleason score value > 7 always had unfavorable prognosis irrespective of treatment. Tumours treated by radical prostatectomy or by radical radiation treatment were associated with a favorable prognosis, as contrasted to the tumours treated by endocrine treatment or those followed-up only, which had a high rate of mortality. Transurethral resection was weakly related to increased risk of death from prostatic adenocarcinoma, although the basic mechanisms behind this observation remain to be explained.
Authors:
S Vesalainen; P Lipponen; S Nordling; M Talja; K Syrjänen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  15     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1995 Mar-Apr
Date Detail:
Created Date:  1995-06-23     Completed Date:  1995-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  569-73     Citation Subset:  IM    
Affiliation:
Department Surgery, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / mortality,  pathology,  therapy*
Adult
Aged
Aged, 80 and over
Aneuploidy
DNA, Neoplasm / analysis
Disease Progression
Disease-Free Survival
Estrogens / therapeutic use*
Finland / epidemiology
Follow-Up Studies
Humans
Life Tables
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Orchiectomy*
Prognosis
Prostatectomy* / methods
Prostatic Neoplasms / mortality,  pathology,  therapy*
Radiotherapy, Adjuvant
Survival Analysis
Treatment Outcome
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Estrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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