|Results of the primary treatment in T1-3M0 prostatic adenocarcinoma are dependent on tumour biology.|
|PMID: 7763039 Owner: NLM Status: MEDLINE|
|The results of the primary treatment were analysed in relation to biological prognostic factors in a series of 215 males with T1-3M0 prostatic adenocarcinoma. T-category, Gleason score and DNA ploidy were significantly related to progression-free survival and overall survival. Incidental tumours usually had a favorable prognosis, 86% of them being diploid, whereas the incidental aneuploid tumours (14%) ran an unfavorable course. In clinically malignant prostates (TPR), neither Gleason score nor DNA ploidy had prognostic significance. The treatment had prognostic significance only in diploid tumours or in tumours with Gleason score value < or = 7, while aneuploid tumours or tumours with Gleason score value > 7 always had unfavorable prognosis irrespective of treatment. Tumours treated by radical prostatectomy or by radical radiation treatment were associated with a favorable prognosis, as contrasted to the tumours treated by endocrine treatment or those followed-up only, which had a high rate of mortality. Transurethral resection was weakly related to increased risk of death from prostatic adenocarcinoma, although the basic mechanisms behind this observation remain to be explained.|
|S Vesalainen; P Lipponen; S Nordling; M Talja; K Syrjänen|
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|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't|
|Title: Anticancer research Volume: 15 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1995 Mar-Apr|
|Created Date: 1995-06-23 Completed Date: 1995-06-23 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE|
|Languages: eng Pagination: 569-73 Citation Subset: IM|
|Department Surgery, University of Kuopio, Finland.|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
DNA, Neoplasm / analysis
Estrogens / therapeutic use*
Finland / epidemiology
Prostatectomy* / methods
Prostatic Neoplasms / mortality, pathology, therapy*
|0/DNA, Neoplasm; 0/Estrogens|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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