Document Detail

Results of a national therapeutic trial conducted in 10,000 hypertensive patients by 2000 general practitioners.
MedLine Citation:
PMID:  282084     Owner:  NLM     Status:  MEDLINE    
1. 10,294 hypertensive patients were treated and followed by 2200 general practitioners under the supervision of 130 cardiologists and nephrologists. 2. The treatment groups, randomly allocated, were designated to use three distinct antihypertensive drugs, administered alone, and combined two-by-two. 3. Some 75% of patients had a supine diastolic blood pressure of less than 95 mmHg after 4 months treatment. 4. A total of 12% of patients had dropped out by 4 months from entry; no clear relationship was established between side effects and drop out.
A Jouve; L Goldet; M Mathieu
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  4     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353s-354s     Citation Subset:  IM    
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MeSH Terms
Amiloride / therapeutic use
Antihypertensive Agents* / adverse effects
Drug Tolerance
Heart Rate
Hydrochlorothiazide / therapeutic use
Hypertension / drug therapy*
Methyldopa / therapeutic use
Middle Aged
Timolol / therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 2609-46-3/Amiloride; 26839-75-8/Timolol; 555-30-6/Methyldopa; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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