| Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke. | |
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MedLine Citation:
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PMID: 15925877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with ischaemic stroke due to occlusion of the basilar or vertebral arteries may develop a rapid deterioration in neurological status leading to coma and often to death. While intra-arterial thrombolysis may be used in this context, no randomised controlled data exist to support its safety or efficacy. METHODS: Randomised controlled trial of intra-arterial urokinase within 24 h of symptom onset in patients with stroke and angiographic evidence of posterior circulation vascular occlusion. RESULTS: Sixteen patients were randomised, and there was some imbalance between groups, with more severe strokes occurring in the treatment arm. A good outcome was observed in 4 of 8 patients who received intra-arterial urokinase compared with 1 of 8 patients in the control group. CONCLUSIONS: These results support the need for a large-scale study to establish the efficacy of intra-arterial thrombolysis for acute basilar artery occlusion. |
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Authors:
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M R Macleod; S M Davis; P J Mitchell; R P Gerraty; G Fitt; G J Hankey; E G Stewart-Wynne; D Rosen; J J McNeil; C F Bladin; B R Chambers; G K Herkes; D Young; G A Donnan |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2005-05-30 |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 20 ISSN: 1015-9770 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2005-09-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 12-7 Citation Subset: IM |
Copyright Information:
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Copyright 2005 S. Karger AG, Basel. |
Affiliation:
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National Stroke Research Institute, Melbourne, Australia. malcolm@apoptosis.freeserve.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants / therapeutic use* Brain Ischemia / drug therapy* Disability Evaluation Female Humans Infusions, Intra-Arterial Male Middle Aged Odds Ratio Plasminogen Activators / administration & dosage, therapeutic use Stroke / drug therapy* Survivors Urokinase-Type Plasminogen Activator / administration & dosage, therapeutic use* Vertebrobasilar Insufficiency / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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