Document Detail

Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese Study Group on Central Precocious Puberty.
MedLine Citation:
PMID:  15598675     Owner:  NLM     Status:  MEDLINE    
We evaluated the effect of leuprorelin treatment on adult height (AH) and followed recovery of reproductive function in 63 girls and 13 boys with central precocious puberty (CPP). Mean treatment durations were 3.8 +/- 2.0 and 4.1 +/- 2.5 yr, and posttreatment follow-up durations were 3.5 +/- 1.3 and 2.6 +/- 1.1 yr for girls and boys, respectively. AH was 154.5 +/- 5.7 cm for girls, and 89.5% of girls reached AH within their target height range. For boys, AH was 163.2 +/- 13.0 cm, and 90.9% reached target height range. It appeared that the Bayley-Pinneau method, modified for Japanese children, using a table for advanced bone age (BA), overestimated AH in CPP; and this method, using a table for average BA and projected height for BA, was suitable for prediction of AH in CPP. Menarche or remenarche occurred in 96.8% of girls at the age of 13.1 +/- 1.5 yr. Of 11 girls who contributed urine samples, all seven idiopathic and two organic cases were considered to have ovulation. Serum testosterone levels reached normal adult level in all boys. In conclusion, long-term leuprorelin treatment for children with CPP improved AH and had no adverse effects on recovery of reproductive function.
Toshiaki Tanaka; Hiroo Niimi; Nobutake Matsuo; Kenji Fujieda; Katsuhiko Tachibana; Kenji Ohyama; Mari Satoh; Koji Kugu
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-14
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-10     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1371-6     Citation Subset:  AIM; IM    
Department of Endocrinology and Metabolism, National Center for Child Health and Development, 2-10-1, Okura, Setagaya, Tokyo, 157-8535, Japan.
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MeSH Terms
Body Height
Fertility Agents, Female / administration & dosage*,  adverse effects
Follow-Up Studies
Leuprolide / administration & dosage*,  adverse effects
Menarche / drug effects
Ovulation / drug effects
Prospective Studies
Puberty, Precocious / drug therapy*
Recovery of Function / drug effects
Reg. No./Substance:
0/Fertility Agents, Female; 53714-56-0/Leuprolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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