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Results of lead research: prenatal exposure and neurological consequences.
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MedLine Citation:
PMID:  8930545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The history of advances in the understanding of the toxic effects of lead over the past 20 years is an outstanding example of how knowledge learned from research can impact public health. Measures that have had the greatest impact on reducing exposure to lead are reduction of lead from gasoline, elimination of lead solder from canned food, removal of lead from paint, and abatement of housing containing lead-based paint. Nevertheless, continuing factors that enhance risk to lead exposure, particularly during fetal life, are low socioeconomic status, old housing with lead-containing paint, and less than ideal nutrition, particularly low dietary intake of calcium, iron, and zinc. Prenatal exposure may result from endogenous sources such as lead in the maternal skeletal system or maternal exposures from diet and the environment. Experimental studies have shown that the developing nervous system is particularly sensitive to the toxic effects of lead and that a large number of the effects in the nervous system are due to interference of lead with biochemical functions dependent on calcium ions and impairment of neuronal connections dependent on dendritic pruning. There is need for more study to determine whether these effects are a continuum of prenatal lead exposure or whether prenatal exposure to lead produces unique effects.
Authors:
R A Goyer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  104     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-20     Completed Date:  1997-02-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1050-4     Citation Subset:  IM    
Affiliation:
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects*
Female
Fetus / drug effects*
Humans
Lead / toxicity*
Pregnancy
Chemical
Reg. No./Substance:
7439-92-1/Lead
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 10 Year: 1996
Volume: 104 Issue: 10
First Page: 1050 Last Page: 1054
ID: 1469478
PubMed Id: 8930545

Results of lead research: prenatal exposure and neurological consequences.
R A Goyer
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.



Article Categories:
  • Research Article


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