| Results of the implementation of liquid-based cytology-SurePath in the Ontario screening program. | |
| | |
MedLine Citation:
|
PMID: 15481083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The objective of the current study was to evaluate the adequacy and detection rates of SurePath after its implementation in Ontario. METHODS: The detection and adequacy rates of the SurePath liquid-based cytology system (SP-LBC) were calculated for manually reviewed slides of the year 2002. The adequacy and detection rates from this study group were compared with a historical conventional smear (CS) group from the same laboratories during the same period of the previous year. RESULTS: The SP-LBC study group consisted of 352,680 specimens with cytodiagnoses and the CS group included 378,990 specimens. The unsatisfactory rate for SP-LBC (0.24%) was less than that of the CS group (0.58%). The detection rate of atypical squamous cells (ASC+) by the SP-LBC group (4.69%) was greater than that of the CS group (3.81%), as was the detection rate of low-grade squamous intraepithelial lesions (LSIL+; 2.13% vs. 1.50% in the CS group). There was only a trend toward increased detection of high-grade squamous intraepithelial lesions (HSIL+) in the SP-LBC group (0.34%) relative to the CS group (0.31%), because the detection rate for carcinoma by SP-LBC declined. CONCLUSIONS: The implementation of SP-LBC has been followed by better specimen adequacy and detection rates for ASC+, LSIL+, and a trend of increased detection of HSIL+ relative to CS practice. To determine sensitivity rates, a histopathologic database for cervical carcinoma and precancer needs to be established. |
| | |
Authors:
|
Terence J Colgan; C Meg McLachlin; Michelle Cotterchio; Robbi Howlett; Allan M Seidenfeld; Verna M Mai |
Related Documents
:
|
17534393 - Neoadjuvant cisplatin and radical cesarean hysterectomy for cervical cancer in pregnancy. 9539523 - Cervical fetal fibronectin correlates to prostaglandin e2-induced cervical ripening and... 11598363 - Effect of betamethasone on computerized cardiotocographic parameters in preterm growth-... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cancer Volume: 102 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2004-12-16 Completed Date: 2005-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 362-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. tcolgan@mtsinai.on.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carcinoma, Squamous Cell
/
diagnosis* Female Humans Mass Screening* Microtomy* Observer Variation Ontario Reproducibility of Results Sensitivity and Specificity Specimen Handling Uterine Cervical Neoplasms / diagnosis* Vaginal Smears / standards* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Successful engraftment following unrelated donor transplant in an alloimmunized patient with Kostman...
Next Document: Ion activation methods for tandem mass spectrometry.