Document Detail

Results from the European multicenter study on lead neurotoxicity in children: implications for risk assessment.
MedLine Citation:
PMID:  2247047     Owner:  NLM     Status:  MEDLINE    
In order to improve dose-response information on neurobehavioral effects of environmental lead exposure in children, the World Health Organization, Regional Office for Europe (WHO/EURO), in collaboration with the Commission of the European Communities, initiated this international study which was planned, executed and evaluated between 1984 and 1989. Eight groups from eight European countries (Bulgaria, Denmark, Greece, Hungary, Italy, Roumania, W. Germany and Yugoslavia) took part. A common study protocol with inherent quality assurance elements was developed to achieve comparability. Blood-lead concentrations (PbB) were the main markers of exposure. The WISC (4 subtests) for psychometric intelligence, the Bender Gestalt test (GFT version) and the Trail-Making test for visual-motor integration, the Vienna Reaction Device and a delayed RT task for reaction performance, and the Needleman scales for behavior ratings served as behavioral endpoints. All individual studies taken together represent a sample size of 1879 school-age children and cover a PbB range from below 5 to about 60 micrograms/100 ml. Overall statistical evaluation of outcome was done by multiple regression analysis using a uniform confounder model. The strongest and most consistent effects occurred for the Bender Gestalt test (GFT version) and for serial choice reaction performance (Vienna Device). The degree of association with PbB was significant for these variables, although the contribution of PbB to the observed variance never exceeded 0.8%. Psychometric intelligence was also negatively affected, although the consistency of outcome between studies was poor, and the association with PbB only borderline. An effort towards risk assessment was made by calculating the proportion of children at risk, using the observed regression coefficients as well as means and standard deviations.
G Winneke; A Brockhaus; U Ewers; U Krämer; M Neuf
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  12     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-01-09     Completed Date:  1991-01-09     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-9     Citation Subset:  IM    
Department of Psychophysiology, Heinrich-Heine-Universität, Düsseldorf, W. Germany.
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MeSH Terms
Child Behavior / drug effects
Intelligence Tests / statistics & numerical data
Lead Poisoning / blood,  psychology*
Nervous System / drug effects*
Psychomotor Performance / drug effects
Quality Control
Reaction Time / drug effects
Tooth / metabolism

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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