Document Detail

Results of directly observed treatment for tuberculosis in Ensenada, Mexico: not all DOTS programs are created equally.
MedLine Citation:
PMID:  17352094     Owner:  NLM     Status:  MEDLINE    
SETTING: Tuberculosis (TB) program in Ensenada, Mexico. OBJECTIVE: To evaluate the impact of the DOTS strategy on adherence and cure rates in everyday practice. DESIGN: Retrospective analysis of 629 patients diagnosed with TB. MEASUREMENTS AND RESULTS: A total of 70% of the patients under directly observed treatment (DOT) were cured vs. 72.8% of those under self-administered treatment (SAT, P = 0.57). There was no difference on the length of therapy according to treatment regimen (4.82 +/- 2.41 for DOT vs. 4.93 +/- 2.16 for SAT, P = 0.61); 16.8% of patients under DOT abandoned treatment vs. 14.1% in the SAT group (P = 0.40). Logistic regression analysis confirmed the previous findings, with length of treatment under 6 months being the strongest predictive variable for treatment failure (OR 18.8, P < 0.00). The type of regimen (DOT vs. SAT) was not predictive of treatment failure (OR for failure for SAT regimen 0.65, P = 0.14). CONCLUSIONS: Cure and completion of treatment rates in our population under study did not differ significantly when comparing DOT vs. SAT. Those in charge of the DOTS programs in a given country need to assess which are the most important ingredients for success in their particular program.
P Radilla-Chávez; R Laniado-Laborín
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  11     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-13     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  IM    
Graduate School of Public Health, Universidad Autónoma de Baja California, Tijuana, México.
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MeSH Terms
Aged, 80 and over
Antitubercular Agents / therapeutic use*
Child, Preschool
Communicable Disease Control / standards*
Directly Observed Therapy / standards*
Logistic Models
Mexico / epidemiology
Middle Aged
Patient Compliance
Retrospective Studies
Treatment Outcome
Tuberculosis, Multidrug-Resistant
Tuberculosis, Pulmonary / drug therapy*,  epidemiology
Reg. No./Substance:
0/Antitubercular Agents

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