Document Detail

Results of combined surgical and medical therapy in patients with prolactin-secreting pituitary macroadenomas.
MedLine Citation:
PMID:  3437957     Owner:  NLM     Status:  MEDLINE    
To assess the long term effectiveness of combined sequential surgical and medical therapy in the management of prolactin-secreting pituitary macroadenomas, we followed 21 patients for 46 +/- 6 months (mean +/- SE) after diagnosis (range, 12 to 96 months). All patients underwent operation. Six were also treated with bromocriptine, 7.5 mg/day immediately after operation. A group of 15 patients with tumor sizes similar to those of the first group was followed without medical therapy until signs of regrowth of the neoplasia were evident. No patient of the combined therapy group experienced a recurrence of the disease. On the other hand, only 2 patients of the second group were recurrence-free at the end of follow-up. In the other 13 cases, adjunctive therapy had to be established for clinical and radiological evidence of tumor recurrence 26 +/- 7 months after operation. We conclude that combined sequential surgical and medical therapy may be useful in the management of macroprolactinomas. Our hypothesis must be confirmed by studies that compare patients treated with operation plus bromocriptine with patients treated with bromocriptine alone.
R Candrina; G Galli; A Bollati; G Pizzocolo; A Orlandini; G F Gualandi; G Giustina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  21     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  894-7     Citation Subset:  IM    
Instituto di Patologia Medica, Universitá di Brescia, Italy.
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MeSH Terms
Adenoma / drug therapy,  secretion,  surgery*
Bromocriptine / therapeutic use*
Combined Modality Therapy
Follow-Up Studies
Middle Aged
Pituitary Neoplasms / drug therapy,  secretion,  surgery*
Prolactin / secretion*
Reg. No./Substance:
25614-03-3/Bromocriptine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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