Document Detail

Results of the Royal Marsden Hospital second soft tissue sarcoma schedule (STS II) chemotherapy regimen in the management of advanced sarcoma.
MedLine Citation:
PMID:  7000348     Owner:  NLM     Status:  MEDLINE    
Forty-eight patients with advanced soft tissue sarcoma were treated with a five-drug combination regimen consisting of vincristine, actinomycin D, and cyclophosphamide (Day 1) followed by doxorubicin and an infusion of methotrexate (Day 22). Thirty-seven of the 48 patients were fully evaluable. Of the 37 evaluable patients, two achieved a complete remission and three achieved a partial remission, with an overall response rate of 13.5%. These results compare unfavorably with previously reported series from this and other centers, and the regimen has now been superseded.
B M Bryant; E Wiltshaw
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Cancer treatment reports     Volume:  64     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:    1980 Apr-May
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-92     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / administration & dosage*
Clinical Trials as Topic
Cyclophosphamide / administration & dosage
Dactinomycin / administration & dosage
Doxorubicin / administration & dosage
Drug Administration Schedule
Drug Therapy, Combination
Methotrexate / administration & dosage
Middle Aged
Sarcoma / drug therapy*,  mortality
Soft Tissue Neoplasms / drug therapy*,  mortality
Vincristine / administration & dosage
Reg. No./Substance:
0/Antineoplastic Agents; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 50-76-0/Dactinomycin; 57-22-7/Vincristine; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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