| Results of extremely-low-birth-weight infants randomized to receive extra enteral calcium supply. | |
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MedLine Citation:
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PMID: 21865980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Bone mineral deficiency continues to occur in extremely-low-birth-weight (ELBW) infants despite formulas enriched in calcium (Ca) and phosphorus (P). This study tested whether extra enteral Ca supplementation increases bone mineral content (BMC) and prevents dolichocephalic head flattening and myopia in ELBW infants. STUDY DESIGN: Infants 401 to 1000 birth weight receiving enteral feeds were randomized to receive feeds supplemented with Ca-gluconate powder or pure standard feeds. The main outcome measures were the excretion of Ca and P by weekly spot urine measurements, the degree of dolichocephalic deformation (fronto-occipital diameter to biparietal diameter ratio, FOD/BPD) at 36 weeks postmenstrual age, and the BMC (by dual-energy x-ray absorptiometry) at discharge. Cycloplegic refraction was measured at 18 to 22 months corrected age. PATIENTS AND RESULTS: Ninety-nine ELBW infants with a gestational age of 26 weeks (23-31) (median [minimum-maximum]) were randomized at a postnatal age of 12 days (5-23) weighing 790 g (440-1700). Urinary Ca excretion increased and P excretion decreased in the Ca-supplemented group. Total BMC was 89.9 ± 2.4 g (mean ± SE) in the supplemented group and 85.2 ± 2.6 g in the control group (P = 0.19). The FOD/BPD was 1.50 (1.13-1.69, mean ± SD [standard deviation]) and 1.47 (1.18-1.64) in the supplemented and control groups, and the refraction 0.98 ± 1.23 and 1.40 ± 1.33 dpt (P = 0.68), respectively in 64 ELBW infants (79% of survivors) at 2-year follow-up. CONCLUSIONS: Extra enteral Ca supplementation did not change BMC, head shape, or refraction. The decreased P excretion may reflect P deficiency in infants receiving extra Ca, preventing improved bone mineral accretion. |
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Authors:
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William F Carroll; Jorge Fabres; Tim R Nagy; Marcela Frazier; Claire Roane; Frank Pohlandt; Waldemar A Carlo; Ulrich H Thome |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 53 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-25 Completed Date: 2011-12-22 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 339-45 Citation Subset: IM |
Affiliation:
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Miami Children's Hospital, Miami, Florida, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00892476 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Bone Density / drug effects* Calcium / deficiency Calcium Gluconate / administration & dosage Calcium, Dietary / administration & dosage* Case-Control Studies Dietary Supplements* Enteral Nutrition Female Follow-Up Studies Humans Infant Infant, Extremely Low Birth Weight / metabolism* Infant, Newborn Male Phosphorus / deficiency |
| Grant Support | |
ID/Acronym/Agency:
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P30 DK056336/DK/NIDDK NIH HHS; P30 DK056336-01/DK/NIDDK NIH HHS; P30DK56336/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium, Dietary; 299-28-5/Calcium Gluconate; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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