Document Detail

Results of catheter-directed endovascular thrombolytic treatment of acute ischaemia of the leg.
MedLine Citation:
PMID:  21055976     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To observe immediate and late results of catheter-directed endovascular thrombolytic treatment of acute ischaemia of the leg.
DESIGN, MATERIAL AND METHODS: A total of 212 patients treated with Actilyse® at the University Hospital of North Norway because of acute arterial ischaemia of the leg during the period 01 January 2000-30 June 2006 were analysed retrospectively.
RESULTS: The radiologic outcome was judged to be successful in 101 (48%), adequate in 80 (38%) and failed in 31 (14%). At 1-year follow-up, 158 (75%) were alive without amputation, 14 (7%) were alive with amputation, 20 (9%) were dead without amputation and 20 (9%) were dead with amputation. Altogether, 34 (16%) were amputated and 40 (19%) were dead after 1 year. After an average observation period of 3.25 years, 111 (52%) were alive without amputation, 16 (8%) were alive with amputation, 60 (28%) were dead without amputation and 25 (12%) were dead with amputation. A total of 41 (19%) were amputated and 85 (40%) were dead. Fifty complications were registered; 30 (14%) patients had a compartment syndrome, eight (4%) had cerebral stroke and 12 (6%) had a myocardial infarction.
CONCLUSIONS: The results are at least as good as historic controls and similar to international series. Especially, it appears as though the long-term results are somewhat better. The complication rate and morbidity are less than in surgery alone.
G A Løkse Nilssen; D Svendsen; K Singh; K Nordhus; D Sørlie
Related Documents :
18573826 - Constraint-induced movement therapy can improve hemiparetic progressive multiple sclero...
3475206 - Long-term evaluation of surgery followed by adjuvant adriamycin in osteogenic sarcoma.
10959506 - Nomograms used to define the short-term treatment with pge(1) in patients with intermit...
18840046 - Selective primary angioplasty following an angiosome model of reperfusion in the treatm...
23623286 - Blood ph is a useful indicator for initiation of therapeutic hypothermia in the early p...
6205676 - The treatment of resistant warts with intralesional bleomycin: a controlled clinical tr...
Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  41     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-02-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Ltd.
Department of Cardiothoracic and Vascular Surgery, University Hospital of North Norway and University of Tromsø, Tromsø, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Aged, 80 and over
Arterial Occlusive Diseases / etiology,  therapy
Fibrinolytic Agents / administration & dosage
Heparin / administration & dosage
Ischemia / drug therapy*,  etiology,  mortality
Leg / blood supply*
Middle Aged
Myocardial Infarction / epidemiology
Retrospective Studies
Stroke / epidemiology
Thromboembolism / complications,  therapy
Thrombolytic Therapy*
Tissue Plasminogen Activator / administration & dosage
Reg. No./Substance:
0/Fibrinolytic Agents; 9005-49-6/Heparin; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like recep...
Next Document:  Cone-beam computerized tomography evaluation of condylar changes and stability following two-jaw sur...