Document Detail


Results of catheter-directed endovascular thrombolytic treatment of acute ischaemia of the leg.
MedLine Citation:
PMID:  21055976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To observe immediate and late results of catheter-directed endovascular thrombolytic treatment of acute ischaemia of the leg.
DESIGN, MATERIAL AND METHODS: A total of 212 patients treated with Actilyse® at the University Hospital of North Norway because of acute arterial ischaemia of the leg during the period 01 January 2000-30 June 2006 were analysed retrospectively.
RESULTS: The radiologic outcome was judged to be successful in 101 (48%), adequate in 80 (38%) and failed in 31 (14%). At 1-year follow-up, 158 (75%) were alive without amputation, 14 (7%) were alive with amputation, 20 (9%) were dead without amputation and 20 (9%) were dead with amputation. Altogether, 34 (16%) were amputated and 40 (19%) were dead after 1 year. After an average observation period of 3.25 years, 111 (52%) were alive without amputation, 16 (8%) were alive with amputation, 60 (28%) were dead without amputation and 25 (12%) were dead with amputation. A total of 41 (19%) were amputated and 85 (40%) were dead. Fifty complications were registered; 30 (14%) patients had a compartment syndrome, eight (4%) had cerebral stroke and 12 (6%) had a myocardial infarction.
CONCLUSIONS: The results are at least as good as historic controls and similar to international series. Especially, it appears as though the long-term results are somewhat better. The complication rate and morbidity are less than in surgery alone.
Authors:
G A Løkse Nilssen; D Svendsen; K Singh; K Nordhus; D Sørlie
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Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  41     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-02-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Ltd.
Affiliation:
Department of Cardiothoracic and Vascular Surgery, University Hospital of North Norway and University of Tromsø, Tromsø, Norway.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Aged, 80 and over
Amputation
Arterial Occlusive Diseases / etiology,  therapy
Catheterization*
Female
Fibrinolytic Agents / administration & dosage
Heparin / administration & dosage
Humans
Ischemia / drug therapy*,  etiology,  mortality
Leg / blood supply*
Male
Middle Aged
Myocardial Infarction / epidemiology
Retrospective Studies
Stroke / epidemiology
Thromboembolism / complications,  therapy
Thrombolytic Therapy*
Tissue Plasminogen Activator / administration & dosage
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 9005-49-6/Heparin; EC 3.4.21.68/Tissue Plasminogen Activator

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