Document Detail

Result of chronic levodopa therapy and its modification by bromocriptine in Parkinson's disease.
MedLine Citation:
PMID:  3984685     Owner:  NLM     Status:  MEDLINE    
15 years' experience with Parkinson's disease treated with levodopa was compared to the 15 years before the advent of levodopa. Progression to severe disability and death was prolonged, at each stage of severity, by 3 to 5 years. At each duration of illness, the percentage of patients with severe disability was reduced significantly. There was some indication that independence was prolonged by early treatment. Life expectancy was increased to approximately that of the unaffected population. However, especially with patients with onset of disease before the age of 50, fluctuations of therapeutic response and severe abnormal involuntary movements interfered with satisfactory therapeutic results. Supplemental bromocriptine produced a smoother therapeutic response and decreased "off" period dystonia and leg pains in over 70% of patients. At dosages below 20 mg daily, it was not particularly effective in severely affected disabled patients. Adverse reactions prevented the use of bromocriptine in less than 20% of patients.
M M Hoehn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  71     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  97-106     Citation Subset:  IM    
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MeSH Terms
Bromocriptine / adverse effects,  therapeutic use*
Carbidopa / adverse effects,  therapeutic use
Disability Evaluation
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Levodopa / adverse effects,  therapeutic use*
Middle Aged
Motor Skills / drug effects
Parkinson Disease / drug therapy*,  mortality
Reg. No./Substance:
0/Levodopa; 25614-03-3/Bromocriptine; 38821-49-7/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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