Document Detail


Restrictive orbital myofibroblastic sarcoma in a cat--cross-sectional imaging (MRI & CT) appearance, treatment, and outcome.
MedLine Citation:
PMID:  23281709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 16-year-old spayed female cat was evaluated for lagophthalmos and chronic exposure keratitis in both eyes. Ophthalmic examination revealed upper and lower eyelid entropion of the left eye (OS) and markedly decreased retropulsion, restricted eye movement, marked episcleral congestion, and severe keratitis of both eyes (OU). Magnetic resonance imaging of both orbits revealed extensive, irregular, contrast-enhancing tissue without evidence of osteolysis considered compatible with diffuse inflammatory tissue. Feline herpesvirus DNA was not detected in conjunctival samples. Partial temporary tarsorrhaphies were placed OU, and the cat was treated with topically administered erythromycin ointment OU, orally administered famciclovir and prednisolone, and sublingually administered buprenorphine. Little improvement was noted after 2 weeks. Six weeks after initial presentation, a left exenteration was performed and histopathology was consistent with idiopathic sclerosing orbital pseudotumor (ISOP). Ten weeks after initial presentation, the patient represented for weight loss and jaw pain. Computed tomography demonstrated disease progression in the right orbit and the patient was euthanized. Histopathology of the decalcified skull revealed an aggressive and highly infiltrative mass involving the right orbit with extension to the maxilla, hard palate, nasal cavity and gingiva most consistent with feline restrictive orbital myofibroblastic sarcoma (FROMS). Clinical data from this patient support the reclassification of ISOP as FROMS. MRI and CT may provide supportive evidence for FROMS, but histopathology is necessary for definitive diagnosis. Aggressive and early surgical treatment, including bilateral exenteration, with adjunctive radiotherapy and/or chemotherapy should be considered for patients with FROMS.
Authors:
Sara M Thomasy; Derek D Cissell; Boaz Arzi; Jose G Vilches-Moure; Winnie Y Lo; Erik R Wisner; Richard R Dubielzig; David J Maggs
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-03
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  16 Suppl 1     ISSN:  1463-5224     ISO Abbreviation:  Vet Ophthalmol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-05     Completed Date:  2014-03-10     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Copyright Information:
© 2013 American College of Veterinary Ophthalmologists.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cat Diseases / pathology*
Cats
Eye Neoplasms / pathology,  veterinary*
Female
Magnetic Resonance Imaging / veterinary*
Sarcoma / classification,  pathology,  veterinary*
Tomography, X-Ray Computed / veterinary*
Grant Support
ID/Acronym/Agency:
K08 EY021142/EY/NEI NIH HHS; K08 EY021142/EY/NEI NIH HHS; T32 OD011147/OD/NIH HHS
Comments/Corrections

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