Document Detail


Restrictive orbital myofibroblastic sarcoma in a cat - Cross-sectional imaging (MRI & CT) appearance, treatment, and outcome.
MedLine Citation:
PMID:  23281709     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A 16-year-old spayed female cat was evaluated for lagophthalmos and chronic exposure keratitis in both eyes. Ophthalmic examination revealed upper and lower eyelid entropion of the left eye (OS) and markedly decreased retropulsion, restricted eye movement, marked episcleral congestion, and severe keratitis of both eyes (OU). Magnetic resonance imaging of both orbits revealed extensive, irregular, contrast-enhancing tissue without evidence of osteolysis considered compatible with diffuse inflammatory tissue. Feline herpesvirus DNA was not detected in conjunctival samples. Partial temporary tarsorrhaphies were placed OU, and the cat was treated with topically administered erythromycin ointment OU, orally administered famciclovir and prednisolone, and sublingually administered buprenorphine. Little improvement was noted after 2 weeks. Six weeks after initial presentation, a left exenteration was performed and histopathology was consistent with idiopathic sclerosing orbital pseudotumor (ISOP). Ten weeks after initial presentation, the patient represented for weight loss and jaw pain. Computed tomography demonstrated disease progression in the right orbit and the patient was euthanized. Histopathology of the decalcified skull revealed an aggressive and highly infiltrative mass involving the right orbit with extension to the maxilla, hard palate, nasal cavity and gingiva most consistent with feline restrictive orbital myofibroblastic sarcoma (FROMS). Clinical data from this patient support the reclassification of ISOP as FROMS. MRI and CT may provide supportive evidence for FROMS, but histopathology is necessary for definitive diagnosis. Aggressive and early surgical treatment, including bilateral exenteration, with adjunctive radiotherapy and/or chemotherapy should be considered for patients with FROMS.
Authors:
Sara M Thomasy; Derek D Cissell; Boaz Arzi; Jose G Vilches-Moure; Winnie Y Lo; Erik R Wisner; Richard R Dubielzig; David J Maggs
Related Documents :
12917789 - Diagnosis of endometriosis.
9127139 - Uterus didelphis with obstructed hemivagina and ipsilateral renal agenesis: ultrasound ...
24097009 - Splenule disguised as pancreatic mass: elucidated with spect liver-spleen scintigraphy.
24331119 - Evaluation of the right ventricle: comparison of gated blood-pool single photon electro...
22245649 - The role of susceptibility weighted imaging in functional mri.
24133389 - Magnetic resonance imaging of vulvar dermatofibrosarcoma protuberans - report of a case.
2570439 - Diagnostic imaging of lower extremity trauma.
11672619 - Exophytic benign tumors of the liver: appearance on mri.
12682789 - Benefit of anatomical-functional image fusion in the diagnostic work-up of neuroendocri...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  -     ISSN:  1463-5224     ISO Abbreviation:  Vet Ophthalmol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American College of Veterinary Ophthalmologists.
Affiliation:
Veterinary Medical Teaching Hospital School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Investigating the relationship of DNA methylation with mutation rate and allele frequency in the hum...
Next Document:  Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.