Document Detail

Restrictive fluid resuscitation in combination with damage control resuscitation: time for adaptation.
MedLine Citation:
PMID:  22929496     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Damage control resuscitation (DCR) conveys a survival advantage in patients with severe hemorrhage. The role of restrictive fluid resuscitation (RFR) when used in combination with DCR has not been elucidated. We hypothesize that RFR, when used with DCR, conveys an overall survival benefit for patients with severe hemorrhage.
METHODS: This is a retrospective analysis from January 2007 to May 2011 at a Level I trauma center. Inclusion criteria included penetrating torso injuries, systolic blood pressure less than or equal to 90 mm Hg, and managed with DCR and damage control surgery (DCS). There were two groups according to the quantity of fluid before DCS: (1) standard fluid resuscitation (SFR) greater than or equal to 150 mL of crystalloid; (2) RFR less than 150 mL of crystalloid. Demographics and outcomes were analyzed.
RESULTS: Three hundred seven patients were included. Before DCS, 132 (43%) received less than 150 mL of crystalloids, grouped under RFR; and 175 (57%) received greater than or equal to 150 mL of crystalloids, grouped under SFR. Demographics and initial clinical characteristics were similar between the study groups. Compared with the SFR group, RFR patients received less fluid preoperatively (129 mL vs. 2,757 mL; p < 0.001), exhibited a lower intraoperative mortality (9% vs. 32%; p < 0.001), and had a shorter hospital length of stay (13 vs. 18 days; p = 0.02). Patients in the SFR group had a lower trauma intensive care unit mortality (5 vs. 12%; p = 0.03) but exhibited a higher overall mortality. Patients receiving RFR demonstrated a survival benefit, with an odds ratio for mortality of 0.69 (95% confidence interval, 0.37-0.91).
CONCLUSION: To the best of our knowledge, this is the first civilian study that analyzes the impact of RFR in patients managed with DCR. Its use in conjunction with DCR for hypotensive trauma patients with penetrating injuries to the torso conveys an overall and early intraoperative survival benefit.
LEVEL OF EVIDENCE: Therapeutic study, level IV.
Marquinn D Duke; Chrissy Guidry; Jordan Guice; Lance Stuke; Alan B Marr; John P Hunt; Peter Meade; Norman E McSwain; Juan Carlos Duchesne
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of trauma and acute care surgery     Volume:  73     ISSN:  2163-0763     ISO Abbreviation:  J Trauma Acute Care Surg     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-29     Completed Date:  2012-11-20     Revised Date:  2013-09-25    
Medline Journal Info:
Nlm Unique ID:  101570622     Medline TA:  J Trauma Acute Care Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-8     Citation Subset:  AIM; IM    
Department of Surgery,Section of Trauma and Critical Care Surgery, Tulane University Health Science Center, New Orleans, Louisiana 70112, USA.
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MeSH Terms
Age Factors
Cohort Studies
Combined Modality Therapy
Confidence Intervals
Critical Illness / mortality,  therapy
Fluid Therapy / methods*
Follow-Up Studies
Hemostasis, Surgical / methods*
Hospital Mortality*
Multivariate Analysis
Resuscitation / methods*,  mortality
Retrospective Studies
Risk Assessment
Safety Management
Shock, Hemorrhagic / diagnosis,  etiology,  mortality*,  therapy*
Survival Rate
Thoracic Injuries / complications,  diagnosis,  therapy
Thoracotomy / methods
Trauma Centers
Treatment Outcome
Wounds, Penetrating / complications,  diagnosis,  therapy
Young Adult

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