| Restrictive cardiomyopathy--an outdated concept? | |
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MedLine Citation:
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PMID: 21528756 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Restrictive cardiomyopathy is probably the least common of all cardiomyopathies, with a nonspecific clinical presentation and a frequently unknown cause. The concept of RCM has changed tremendously over time. Today it includes a large panel of disorders characterized by a non-hypertrophied, non-dilated cardiac phenotype and a restrictive ventricular filling pattern. Several unsuccessful attempts to define and classify cardiomyopathies have been made, but they all proved problematic due to the contradiction in terms and the overlap between classical patterns. Advances in disease pathology, genomics and molecular biology are emerging as the framework of a new revolutionary classification system, focused on the dynamic interaction between genotype and phenotype. In this context, RCM is evolving as a self-contained hemodynamic and pathophysiological concept, although questionable due to its uncertain practical utility. |
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Authors:
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Carmen Ginghină; Raluca Mihalache; B A Popescu; Ruxandra Jurcuţ |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Romanian journal of internal medicine = Revue roumaine de médecine interne Volume: 48 ISSN: 1220-4749 ISO Abbreviation: Rom J Intern Med Publication Date: 2010 |
Date Detail:
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Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304507 Medline TA: Rom J Intern Med Country: Romania |
Other Details:
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Languages: eng Pagination: 293-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. carmenginghina2010@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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