| Restrictive right ventricular physiology and right ventricular fibrosis as assessed by cardiac magnetic resonance and exercise capacity after biventricular repair of pulmonary atresia and intact ventricular septum. | |
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MedLine Citation:
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PMID: 20186992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The hypertrophic myocardium, myocardial fiber disarray, and endocardial fibroelastosis in pulmonary atresia and intact ventricular septum (PAIVS) may provide anatomic substrates for restrictive filling of the right ventricle. HYPOTHESIS: Restrictive right ventricle (RV) physiology is related to RV fibrosis and exercise capacity in patients after biventricular repair of PAIVS. METHODS: A total of 27 patients, age 16.5 +/- 5.6 years, were recruited after biventricular repair of PAIVS. Restrictive RV physiology was defined by the presence of antegrade diastolic pulmonary flow and RV fibrosis assessed by late gadolinium enhancement (LGE) cardiac magnetic resonance. Their RV function was compared with that of 27 healthy controls and related to RV LGE score and exercise capacity. RESULTS: Compared with controls, PAIVS patients had lower tricuspid annular systolic and early diastolic velocities, RV global longitudinal systolic strain, systolic strain rate, and early and late diastolic strain rates (all P < 0.05). A total of 22 (81%, 95% confidence interval: 62%-94%) PAIVS patients demonstrated restrictive RV physiology. Compared to those without restrictive RV physiology (n = 5), these 22 patients had lower RV global systolic strain, lower RV systolic and early diastolic strain rates, higher RV LGE score, and a greater percent of predicted maximum oxygen consumption (all P < 0.05). CONCLUSION: Restrictive RV physiology reflects RV diastolic dysfunction and is associated with more severe RV fibrosis but better exercise capacity in patients after biventricular repair of PAIVS. |
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Authors:
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Xue-Cun Liang; W W M Lam; E W Y Cheung; A K P Wu; Sophia J Wong; Yiu-Fai Cheung |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 33 ISSN: 1932-8737 ISO Abbreviation: Clin Cardiol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 104-10 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley Periodicals, Inc. |
Affiliation:
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Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Balloon Dilatation Cardiac Surgical Procedures* / adverse effects Cardiomyopathy, Restrictive / diagnosis*, etiology, physiopathology Case-Control Studies Contrast Media / diagnostic use Echocardiography, Doppler Exercise Test* Exercise Tolerance* Female Fibrosis Gadolinium DTPA / diagnostic use Heart Ventricles / pathology, physiopathology Humans Magnetic Resonance Imaging* Male Oxygen Consumption Predictive Value of Tests Pulmonary Atresia / complications, diagnosis, physiopathology, surgery* Pulmonary Circulation Severity of Illness Index Treatment Outcome Ventricular Dysfunction, Right / diagnosis*, etiology, physiopathology Ventricular Function, Right* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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