| Restriction of placental vasculature in a non-human primate: a unique model to study placental plasticity. | |
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MedLine Citation:
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PMID: 22030304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The limits of placental plasticity, i.e., the ability of the placenta to adapt and alter its growth trajectory in response to altered fetal requirements, are not known. We report fetal and placental hemodynamic adaptations in a novel non-human primate model in which the fetal inter-placental bridging vessels were surgically ligated. Doppler ultrasound studies showed that the rhesus placenta compensates for an approximate 40% reduction in functional capacity by increased growth and maintenance of umbilical volume blood flow. This unique experimental animal model has applications for mechanistic studies of placental plasticity and the impact on fetal development. |
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Authors:
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V H J Roberts; J P Räsänen; M J Novy; A Frias; S Louey; T K Morgan; K L Thornburg; E R Spindel; P L Grigsby |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-26 |
Journal Detail:
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Title: Placenta Volume: 33 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-30 Completed Date: 2012-05-11 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 73-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center (ONPRC), Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA. robertsv@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Disease Models, Animal* Female Fetal Development* Fetal Growth Retardation / physiopathology Hemodynamics Ligation / adverse effects Macaca mulatta / physiology* Placenta / blood supply, pathology, physiopathology, surgery Placental Circulation* Placentation* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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4R00 HD055053/HD/NICHD NIH HHS; K99 HD055059/HD/NICHD NIH HHS; P51 RR000163-50/RR/NCRR NIH HHS; R00 HD055053-04/HD/NICHD NIH HHS; R01 HL087710/HL/NHLBI NIH HHS; R01 HL087710-10/HL/NHLBI NIH HHS; RR00163/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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