Document Detail

Restriction of placental vasculature in a non-human primate: a unique model to study placental plasticity.
MedLine Citation:
PMID:  22030304     Owner:  NLM     Status:  MEDLINE    
The limits of placental plasticity, i.e., the ability of the placenta to adapt and alter its growth trajectory in response to altered fetal requirements, are not known. We report fetal and placental hemodynamic adaptations in a novel non-human primate model in which the fetal inter-placental bridging vessels were surgically ligated. Doppler ultrasound studies showed that the rhesus placenta compensates for an approximate 40% reduction in functional capacity by increased growth and maintenance of umbilical volume blood flow. This unique experimental animal model has applications for mechanistic studies of placental plasticity and the impact on fetal development.
V H J Roberts; J P Räsänen; M J Novy; A Frias; S Louey; T K Morgan; K L Thornburg; E R Spindel; P L Grigsby
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-26
Journal Detail:
Title:  Placenta     Volume:  33     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-30     Completed Date:  2012-05-11     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Adaptation, Physiological*
Disease Models, Animal*
Fetal Development*
Fetal Growth Retardation / physiopathology
Ligation / adverse effects
Macaca mulatta / physiology*
Placenta / blood supply,  pathology,  physiopathology,  surgery
Placental Circulation*
Grant Support
4R00 HD055053/HD/NICHD NIH HHS; K99 HD055059/HD/NICHD NIH HHS; P51 RR000163/RR/NCRR NIH HHS; P51 RR000163-50/RR/NCRR NIH HHS; R00 HD055053-04/HD/NICHD NIH HHS; R01 HL087710/HL/NHLBI NIH HHS; R01 HL087710-10/HL/NHLBI NIH HHS; RR00163/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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