Document Detail


Restricticin, a novel glycine-containing antifungal agent.
MedLine Citation:
PMID:  2061189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Restricticin (1) is a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities and is unrelated to any previously known family of natural products. This unstable compound, as well as its corresponding N,N-dimethyl derivative (2), have been produced and isolated from both solid and liquid fermentations of Penicillium restrictum. The desglycyl hydrolysis product, restrictinol (3), was produced via the hydrolysis of pure restricticin and as an artifact of the isolation of restricticin.
Authors:
R E Schwartz; C Dufresne; J E Flor; A J Kempf; K E Wilson; T Lam; J Onishi; J Milligan; R A Fromtling; G K Abruzzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  44     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  463-71     Citation Subset:  IM    
Affiliation:
Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / isolation & purification*,  pharmacology
Drug Stability
Fermentation
Glycine / analogs & derivatives*,  isolation & purification,  pharmacology
Microbial Sensitivity Tests
Penicillium / analysis,  metabolism
Pyrans / isolation & purification*,  pharmacology
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrans; 135357-96-9/restricticin; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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