Document Detail

Restricticin, a novel glycine-containing antifungal agent.
MedLine Citation:
PMID:  2061189     Owner:  NLM     Status:  MEDLINE    
Restricticin (1) is a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities and is unrelated to any previously known family of natural products. This unstable compound, as well as its corresponding N,N-dimethyl derivative (2), have been produced and isolated from both solid and liquid fermentations of Penicillium restrictum. The desglycyl hydrolysis product, restrictinol (3), was produced via the hydrolysis of pure restricticin and as an artifact of the isolation of restricticin.
R E Schwartz; C Dufresne; J E Flor; A J Kempf; K E Wilson; T Lam; J Onishi; J Milligan; R A Fromtling; G K Abruzzo
Related Documents :
8500779 - Antimicrobial effects of some dicarbonyl and tricarbonyl sugar hydrazone derivatives.
17532639 - Synthesis, antifungal and antimicrobial activity of alkylphospholipids.
19414029 - Antimicrobial activity of hydroxylbenzenesulfonailides derivatives of chitosan, chitosa...
19082779 - Use of galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [ag2(...
10513629 - Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, ...
15217189 - Fr171456, a novel cholesterol synthesis inhibitor produced by sporormiella minima no. 1...
22749419 - Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent...
19805269 - Quantification of rapid environmental redox processes with quick-scanning x-ray absorpt...
17010479 - Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate i...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  44     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  463-71     Citation Subset:  IM    
Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antifungal Agents / isolation & purification*,  pharmacology
Drug Stability
Glycine / analogs & derivatives*,  isolation & purification,  pharmacology
Microbial Sensitivity Tests
Penicillium / analysis,  metabolism
Pyrans / isolation & purification*,  pharmacology
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrans; 135357-96-9/restricticin; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relations among synovial membrane histopathologic findings, synovial fluid cytologic findings, and b...
Next Document:  Kedarcidin, a new chromoprotein antitumor antibiotic. I. Taxonomy of producing organism, fermentatio...