Document Detail

Restricted-range gradients and travelling fronts in a model of juxtacrine cell relay.
MedLine Citation:
PMID:  9739619     Owner:  NLM     Status:  MEDLINE    
Patterning events in development often depend on the transmission over a range of several cell diameters of signals emanating from a localized source. Experimental studies of such long-range signalling by members of the TGF-beta family of growth factors suggests that a cell-relay mechanism in which cells signal only with their immediate neighbours (i.e., juxtacrine signalling) may be operating in some tissues. Here, this possibility is investigated through the analysis of a model of juxtacrine signalling. Depending on the strength of the signal relay between cells, a localized signal source can generate either stable gradients or travelling fronts of cell activation. Both of these behaviors could in principle be involved in the long-range transmission of signals and patterning of cell fates by cell relays. There are significant and surprising differences between the gradients generated by the mechanism studied here, and those generated by the diffusion of a morphogen. In particular, there is an upper limit on the distance over which any given level of cell activation can be attained in a relay-mediated gradient. irrespective of the strength of signal source.
N A Monk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of mathematical biology     Volume:  60     ISSN:  0092-8240     ISO Abbreviation:  Bull. Math. Biol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-09     Completed Date:  1998-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401404     Medline TA:  Bull Math Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  901-18     Citation Subset:  IM    
Centre for Mathematical Biology, Mathematical Institute, University of Oxford, U.K.
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MeSH Terms
Biological Transport, Active
Cell Communication / physiology*
Computer Simulation*
Models, Biological*
Receptors, Cell Surface / metabolism*,  physiology
Signal Transduction / physiology*
Time Factors
Transforming Growth Factor beta / metabolism,  physiology
Reg. No./Substance:
0/Ligands; 0/Receptors, Cell Surface; 0/Transforming Growth Factor beta

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