Document Detail


Restrained ion population transfer: a novel ion transfer method for mass spectrometry.
MedLine Citation:
PMID:  18489013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fourier transform ion cyclotron resonance (FTICR) mass spectrometers function such that the ion accumulation event takes place in a region of higher pressure outside the magnetic field which allows ions to be thermally cooled before being accelerated toward the ICR cell where they are decelerated and re-trapped. This transfer process suffers from mass discrimination due to time-of-flight effects. Also, trapping ions with substantial axial kinetic energy can decrease the performance of the FTICR instrument compared with the analysis of thermally cooled ions located at the trap center. Therefore, it is desirable to limit the energy imparted to the ions which results in lower applied trap plate potentials and reduces the spread in axial kinetic energy. The approach presented here for ion transfer, called restrained ion population transfer or RIPT, is designed to provide complete axial and radial containment of an ion population throughout the entire transfer process from the accumulation region to the ICR cell, eliminating mass discrimination associated with time-of-flight separation. This was accomplished by use of a number of quadrupole segments arranged in series with independent control of the direct current (DC) bias voltage applied to each segment of the quadrupole ion guide. The DC bias voltage is applied in such a way as to minimize the energy imparted to the ions allowing transfer of ions with low kinetic energy from the ion accumulation region to the ICR cell. Initial FTICR mass spectral data are presented that illustrate the feasibility of RIPT. A larger m/z range for a mixture of peptides is demonstrated compared with gated trapping. The increase in ion transfer time (3 ms to 130 ms) resulted in an approximately 11% decrease in the duty cycle; however this can be improved by simultaneously transferring multiple ion populations with RIPT. The technique was also modeled with SIMION 7.0 and simulation results that support our feasibility studies of the ion transfer process are presented.
Authors:
Nathan K Kaiser; Gunnar E Skulason; Chad R Weisbrod; Si Wu; Kai Zhang; David C Prior; Michael A Buschbach; Gordon A Anderson; James E Bruce
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  22     ISSN:  0951-4198     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-07-23     Revised Date:  2010-06-29    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  1955-64     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA.
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation
Cyclotrons
Ions*
Mass Spectrometry / instrumentation*,  methods*
Spectroscopy, Fourier Transform Infrared / methods
Thermodynamics
Grant Support
ID/Acronym/Agency:
T32 GM008336-17/GM/NIGMS NIH HHS; T32 GM008336-18/GM/NIGMS NIH HHS; T32 GM008336-19/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Ions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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