Document Detail

Restoration of retinal blood flow via translumenal Nd:YAG embolysis/embolectomy (TYL/E) for central and branch retinal artery occlusion.
MedLine Citation:
PMID:  18301027     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO) may be a result of platelet-fibrin emboli, cholesterol plaques, or calcific emboli that typically lodge at the bifurcation of retinal arterioles or at a location as the vessel narrows. Hollenhorst plaques (cholesterol emboli) can often be seen at the site of vessel obstruction. Obstruction of blood flow results in partial or complete retinal ischemia and sudden loss of vision. There is no effective therapy for CRAO and BRAO. The authors employed the Nd:YAG laser to photodisrupt emboli within the central retinal artery (CRA) and branch retinal arteries (BRA) to achieve rapid reperfusion of the retina. METHODS: Translumenal Nd:YAG embolysis (TYL) or embolectomy (TYE) was performed on 19 patients with sight-threatening CRAO or BRAO. All patients had a visible embolus within the CRA or BRA. A fundus contact lens was used to focus the Nd:YAG laser on the embolus within the retinal arteriole. Laser applications were delivered directly to the embolus with increasing energy until the embolus was either fragmented within the lumen (embolysis) or was observed to pass into the vitreous through a small opening in the arteriole (embolectomy). RESULTS: TYL/E was achieved in all 19 patients. In 8 patients the emboli was fragmented (embolysis) and in 11 the embolus was transplaced into the vitreous (embolectomy). Reperfusion of the retina was observed in all patients as determined by fundus examination, fundus photography, and fluorescein angiography. Snellen visual acuity improved by an average of 4.7 lines (range, 1-11 lines) in 17/19 (89%) patients. Eleven of the patients (58%) gained greater than 4 lines. One patient had no improvement and another lost one line due to a persistent vitreous hemorrhage. Vitreous hemorrhage (VH) occurred in seven patients, and subhyaloid hemorrhage (SH) occurred in one patient. In five of the patients an early vitrectomy was performed to allow clinical assessment and documentation of the successful TYL/E. CONCLUSION: Photodisruption of an embolus within an occluded CRA or BRA can be achieved via TYL/E. Rapid reperfusion of the retina is associated with anatomic and visual acuity improvement. Translumenal Nd:YAG embolysis or embolectomy of a visible embolus in patients with CRAO or BRAO can be achieved resulting in restoration of retinal blood flow and improved visual function.
Emitchel Opremcak; Alan J Rehmar; Chet D Ridenour; Lisa M Borkowski; James K Kelley
Related Documents :
11004107 - Ocular features in rubinstein-taybi syndrome: investigation of 24 patients and review o...
21359057 - Characteristics of late-onset epilepsy and eeg findings in children with autism spectru...
11753827 - Discontinuation of secondary prophylaxis in patients with cytomegalovirus retinitis who...
25241327 - Development of the lémann index to assess digestive tract damage in patients with croh...
19775537 - Added diagnostic utility of ct perfusion and ct angiography in acute ischemic stroke. e...
7517527 - Inappropriate sinus tachycardia following radiofrequency ablation of av nodal tachycard...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  28     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-27     Completed Date:  2008-04-22     Revised Date:  2009-05-13    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-35     Citation Subset:  IM    
The Retina Group, Columbus, OH 43215, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Embolectomy / methods*
Fluorescein Angiography
Fundus Oculi
Laser Coagulation / methods*
Middle Aged
Regional Blood Flow / physiology
Retinal Artery / physiology*
Retinal Artery Occlusion / physiopathology,  surgery*
Visual Acuity
Comment In:
Retina. 2009 Feb;29(2):285; author reply 285   [PMID:  19202430 ]
Retina. 2008 Oct;28(9):1369-72; author reply 1372-3   [PMID:  19430398 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Visual acuity and multifocal electroretinographic changes after arteriovenous crossing sheathotomy f...
Next Document:  Vitreous dynamics: vitreous flow analysis in 20-, 23-, and 25-gauge cutters.