Document Detail

Restoration of peritoneal integrity after withdrawal of peritoneal dialysis: characteristic features of the patients at risk of encapsulating peritoneal sclerosis.
MedLine Citation:
PMID:  16362159     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The epidemiological characteristics of encapsulating peritoneal sclerosis (EPS), such as its high incidence in patients with long-term peritoneal dialysis (PD) treatment, and the onset of EPS after patients are switched to hemodialysis (HD) may indicate an activated pathological process after PD withdrawal, especially in long-term PD patients. Accordingly, we aimed to observe changes in peritoneal function after the stoppage of PD, and to clarify the characteristic features of the patients at risk of EPS. METHODS: Thirty-three patients who were switched from continuous ambulatory peritoneal dialysis (CAPD) to HD were enrolled in this trial. Changes in the dialysate/plasma creatinine (D/P Cr) and CA125 levels in the effluent of the peritoneal equilibration test were observed for 6 months. Furthermore, each patient was followed-up for 36 months after PD withdrawal to monitor for the development of EPS. RESULTS: D/P Cr decreased significantly, while CA125 levels tended to increase. Nine patients developed EPS during the follow-up period and they specifically showed significant increases of D/P Cr levels and significantly lower levels of CA125 at PD withdrawal. The accumulation of high transporters in the EPS group at 0 and 6 months after PD withdrawal was significant. CONCLUSIONS: Peritoneal recovery may take place after withdrawal from PD treatment and such recover indicated by improvement of transport states and a rise of the CA125 level. The present study revealed that a high-transport state and lack of increase of CA125 in the effluent were associated with EPS development after PD withdrawal. This may suggest that the lack of peritoneal recovery after PD withdrawal is predictive for EPS development.
Yasushi Otsuka; Masaaki Nakayama; Masato Ikeda; Ali M Sherif; Keitaro Yokoyama; Hiroyasu Yamamoto; Yoshindo Kawaguchi
Related Documents :
16362159 - Restoration of peritoneal integrity after withdrawal of peritoneal dialysis: characteri...
7455629 - Polymyalgia arteritica. a report on five cases within a family.
9550649 - Simultaneous peritoneal dialysis catheter insertion and removal in catheter-related inf...
17179509 - Impact of nutritional status on peritonitis in capd patients.
9677719 - Persistent diffuse peritonitis in children.
7851559 - Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis.
12567109 - Hyperhomocystinemia in pseudoexfoliation glaucoma.
12637679 - Camera-based fdg pet and 67ga spect in evaluation of lymphoma: comparative study.
9749579 - Mitochondria in the etiology and pathogenesis of parkinson's disease.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  9     ISSN:  1342-1751     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-06     Revised Date:  2006-03-01    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Tokyo 105-8461, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
CA-125 Antigen / metabolism
Creatinine / metabolism
Follow-Up Studies
Kidney Failure, Chronic / therapy*
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
Peritoneum / metabolism,  pathology
Peritonitis / epidemiology,  etiology*,  pathology*
Recovery of Function
Renal Dialysis*
Risk Factors
Reg. No./Substance:
0/CA-125 Antigen; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Imbalance between production and scavenging of hydroxyl radicals in patients maintained on hemodialy...
Next Document:  Nephronophthisis in two siblings.