| Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication. | |
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MedLine Citation:
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PMID: 15973100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the mechanical characteristics of the esophagogastric junction (EGJ) of postfundoplication patients and compare them with previously reported data on normal subjects and GERD patients. METHODS: Eight normal subjects, 9 GERD patients, and 8 fundoplication patients were studied with concurrent manometry, fluoroscopy, and stepwise controlled barostat distention of the EGJ. The minimal barostat pressure required to open the EGJ during the interswallow period was determined. Thereafter, barium swallows were imaged in 5-mm Hg increments of intrabag pressure. EGJ diameter and length were measured at each pressure during deglutitive relaxation. RESULTS: EGJ opening diameter during deglutitive relaxation was on average 0.5 cm greater in GERD patients compared with normal subjects and fundoplication patients (P < 0.05). EGJ opening pressure and opening diameter were comparable between normal subjects and fundoplication patients; however, the EGJ length was 32% longer in fundoplication patients. CONCLUSIONS: Fundoplication restores distensibility of the EGJ to a level similar to normal subjects. Since trans-EGJ flow is related to EGJ length and EGJ diameter, these findings suggest that retrograde flow through the EGJ would be decreased by both a reduction in diameter and an increase in length of the EGJ. |
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Authors:
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John E Pandolfino; Jennifer Curry; Guoxiang Shi; Raymond J Joehl; James G Brasseur; Peter J Kahrilas |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of surgery Volume: 242 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-23 Completed Date: 2005-08-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: United States |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Northwestern University Medical School, Chicago, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Endoscopy, Gastrointestinal / methods Esophagogastric Junction / physiopathology, surgery* Female Follow-Up Studies Fundoplication / methods* Gastroesophageal Reflux / diagnosis, surgery* Hernia, Hiatal / diagnosis, surgery* Humans Male Manometry Middle Aged Postoperative Complications Recovery of Function Reference Values Risk Assessment Severity of Illness Index Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK062170-01/DK/NIDDK NIH HHS; R01 DC00646/DC/NIDCD NIH HHS |
| Comments/Corrections | |
Comment In:
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Ann Surg. 2006 Feb;243(2):288; author reply 288-9
[PMID:
16432367
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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