| Restoration of nitric oxide function in human hyperlipidaemia, congestive heart failure and liver cirrhosis. | |
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MedLine Citation:
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PMID: 9750951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. There is accumulating evidence for a range of abnormalities in the nitric oxide (NO) signalling cascade in human cardiovascular disorders. 2. In the present review we assess the literature detailing such evidence in early (hyperlipidaemia) and end-stage (heart failure) disease, with emphasis on the mechanisms by which the disturbances are thought to occur. 3. Strategies for the correction of disturbed NO signalling in these states are reviewed and include both prescribed pharmacological interventions, such as lipid-lowering therapy and novel uses of angiotensin-converting enzyme inhibitors, as well as non-pharmacological interventions, such as exercise and dietary supplementation with L-arginine and n-3 polyunsaturated fatty acids. 4. In addition to a decreased production/function of NO, the possible detrimental effects of a chronic elevation in NO production in patients with liver cirrhosis, together with a novel use of antibiotics to correct this perturbation, is outlined. |
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Authors:
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J P Chin-Dusting; D M Kaye |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 25 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-11-18 Completed Date: 1998-11-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 645-52 Citation Subset: IM |
Affiliation:
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Alfred and Baker Medical Unit, Baker Medical Research Institute, Victoria, Australia. jaye.chin@baker.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Heart Failure
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physiopathology* Humans Hyperlipidemias / physiopathology* Liver Cirrhosis / physiopathology* Nitric Oxide / physiology* Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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