| Restoration of coronary blood flow by single bolus injection of the GPIIb/IIIa receptor antagonist c7E3 Fab in a patient with acute myocardial infarction of recent onset. | |
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MedLine Citation:
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PMID: 9669064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been debated that primary coronary angioplasty could be more effective if immediate antithrombotic therapy would contribute to a faster recanalization of the infarct-related artery. This is the first report of a patient who presented at the emergency department with acute anterolateral myocardial infarction, in whom a single bolus injection of c7E3 Fab (0.25 mg/kg body weight) led to complete reperfusion of the infarct-related coronary artery during organization time for planned acute coronary angioplasty. Pain relief 15 min after initiation of therapy and ST-segment resolution of > 50%, as well as occurrence of idioventricular rhythm 30 min thereafter, were suggestive of successful recanalization before the coronary intervention was started. Diagnostic coronary angiography at 90 min revealed TIMI-grade 3 flow in the infarct-related coronary artery with only moderate luminal irregularities. Bolus administration of c7E3 Fab could be effective for dissolving platelet-rich thrombi in the early stage of acute myocardial infarction (AMI) and may therefore represent a promising "bridging" therapy in patients with AMI elected for primary coronary angioplasty. |
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Authors:
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H Domanovits; M Nikfardjam; K Janata; S Hornykewycz; G Maurer; A N Laggner; K Huber |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 21 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-09-28 Completed Date: 1998-09-28 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 525-8 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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administration & dosage* Coronary Angiography Coronary Vessels / physiopathology* Electrocardiography / drug effects Follow-Up Studies Humans Immunoglobulin Fab Fragments / administration & dosage* Infusions, Intravenous Male Middle Aged Myocardial Infarction / drug therapy*, physiopathology, radiography Platelet Aggregation Inhibitors / administration & dosage* Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors* Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 143653-53-6/abciximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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