Document Detail


Restoration of bone mass in hpg mouse by preoptic area grafting.
MedLine Citation:
PMID:  16831935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hereditary hypogonadism in the hpg mouse, caused by a deletion mutation in the gonadotropin-releasing hormone (GnRH) gene, is associated with sterility, absent ovarian development, and undetectable circulating sex steroids. Eight-month-old female hpg mice had a significantly reduced bone mineral density (BMD) at the lumbar spine, femur, and tibia. In addition, the mice showed significant reductions in liver and kidney weight, with virtually nonexistent ovaries. Successfully transplanted hpg mice with preoptic area grafts contained GnRH-positive neurons, consistent with our previous experience, and the host median eminence was innervated by GnRH immunoreactive fibers. A return of reproductive function was evident from increased ovarian weight and vaginal cornification. Of note was that grafted hpg mice showed a complete reversal to baseline of their BMD measured at all three sites. This establishes that the low bone mass that occurs in old hpg mice can be fully and rapidly ameliorated by preoptic area grafting.
Authors:
Gopalan Rajendren; Hang Zhou; Baljit S Moonga; Mone Zaidi; Li Sun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1068     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-07-11     Completed Date:  2006-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, The Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Density / physiology*
Disease Models, Animal
Female
Gonadotropin-Releasing Hormone / deficiency*
Hypogonadism / genetics*
Male
Mice
Mice, Knockout
Mutagenesis
Sequence Deletion
Spine
Grant Support
ID/Acronym/Agency:
AG23176/AG/NIA NIH HHS; DK70526/DK/NIDDK NIH HHS; R01 AG14197/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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