| Restoration of barrier function in injured intestinal mucosa. | |
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MedLine Citation:
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PMID: 17429041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mucosal repair is a complex event that immediately follows acute injury induced by ischemia and noxious luminal contents such as bile. In the small intestine, villous contraction is the initial phase of repair and is initiated by myofibroblasts that reside immediately beneath the epithelial basement membrane. Subsequent events include crawling of healthy epithelium adjacent to the wound, referred to as restitution. This is a highly regulated event involving signaling via basement membrane integrins by molecules such as focal adhesion kinase and growth factors. Interestingly, however, ex vivo studies of mammalian small intestine have revealed the importance of closure of the interepithelial tight junctions and the paracellular space. The critical role of tight junction closure is underscored by the prominent contribution of the paracellular space to measures of barrier function such as transepithelial electrical resistance. Additional roles are played by subepithelial cell populations, including neutrophils, related to their role in innate immunity. The net result of reparative mechanisms is remarkably rapid closure of mucosal wounds in mammalian tissues to prevent the onset of sepsis. |
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Authors:
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Anthony T Blikslager; Adam J Moeser; Jody L Gookin; Samuel L Jones; Jack Odle |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Physiological reviews Volume: 87 ISSN: 0031-9333 ISO Abbreviation: Physiol. Rev. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-12 Completed Date: 2007-05-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231714 Medline TA: Physiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 545-64 Citation Subset: IM |
Affiliation:
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Department of Clinical Science, North Carolina State University, Raleigh 27606, USA. Anthony_Blikslager@ncsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Epithelial Cells / physiology Humans Inflammation / pathology Intestinal Diseases / pathology*, physiopathology Intestinal Mucosa / cytology, pathology*, physiopathology Mucous Membrane / cytology, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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