Document Detail


Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR.
MedLine Citation:
PMID:  9717434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The house mouse, Mus musculus, harbours a variable cluster of long-range repeats in chromosome 1. As shown in previous studies, some high-copy clusters such as the MUT cluster are cytogenetically apparent as a homogeneously staining region (HSR) and are associated with a distortion of the Mendelian recovery ratio when transmitted by heterozygous females. The effect is caused by a decreased viability of +/+ embryos. It is compensated by maternal or paternal MUT. In this study, a deletion derivative of MUT, MUTdel, shows normal transmission ratios and no compensating capability. In this respect, MUTdel behaves like a wild-type cluster. Hence, both properties--transmission ratio distortion and compensating capability--map to the deleted region. The deletion comprises three-quarters of the MUT HSR and does not extend to the nearest markers adjacent to the HSR.
Authors:
D Weichenhan; B Kunze; W Traut; H Winking
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetical research     Volume:  71     ISSN:  0016-6723     ISO Abbreviation:  Genet. Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-09-15     Completed Date:  1998-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370741     Medline TA:  Genet Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Affiliation:
Institut für Biologie, Medizinische Universität zu Lübeck, Germany. weichenh@molbio.mu-leubeck.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Deletion*
Chromosome Mapping
Female
Genomic Imprinting
Heterozygote
Homozygote
Mice / genetics*

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