Document Detail

Restless legs syndrome and low brain iron levels in patients with haemochromatosis.
MedLine Citation:
PMID:  15965214     Owner:  NLM     Status:  MEDLINE    
Regional brain iron levels of two patients with haemochromatosis and severe restless legs syndrome (RLS) were assessed using R2' magnetic resonance imaging (MRI) sequences in both patients and in nine healthy controls. R2' relaxation rates in the patients were decreased in the substantia nigra, red nucleus, and pallidum when compared with the controls. These results indicate that local brain iron deficiency may occur in patients with haemochromatosis and suggest a role for brain iron metabolism in the pathophysiology of RLS.
J Haba-Rubio; L Staner; C Petiau; G Erb; T Schunck; J P Macher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  76     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-20     Completed Date:  2005-07-19     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1009-10     Citation Subset:  IM    
Institute for Research in Neurosciences and Neuropsychiatry, Rouffach, France.
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MeSH Terms
Brain / pathology*
Brain Diseases / diagnosis*,  genetics*
Caudate Nucleus / pathology
Ferritins / metabolism
Globus Pallidus / pathology
Hemochromatosis / diagnosis*,  genetics*
Histocompatibility Antigens Class I / genetics
Image Processing, Computer-Assisted
Iron / metabolism*
Magnetic Resonance Imaging*
Membrane Proteins / genetics
Middle Aged
Putamen / pathology
Red Nucleus / pathology
Reference Values
Restless Legs Syndrome / diagnosis*,  genetics*
Substantia Nigra / pathology
Reg. No./Substance:
0/HFE protein, human; 0/Histocompatibility Antigens Class I; 0/Membrane Proteins; 7439-89-6/Iron; 9007-73-2/Ferritins

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