| Restless legs syndrome and low brain iron levels in patients with haemochromatosis. | |
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MedLine Citation:
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PMID: 15965214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional brain iron levels of two patients with haemochromatosis and severe restless legs syndrome (RLS) were assessed using R2' magnetic resonance imaging (MRI) sequences in both patients and in nine healthy controls. R2' relaxation rates in the patients were decreased in the substantia nigra, red nucleus, and pallidum when compared with the controls. These results indicate that local brain iron deficiency may occur in patients with haemochromatosis and suggest a role for brain iron metabolism in the pathophysiology of RLS. |
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Authors:
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J Haba-Rubio; L Staner; C Petiau; G Erb; T Schunck; J P Macher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 76 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-20 Completed Date: 2005-07-19 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 1009-10 Citation Subset: IM |
Affiliation:
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Institute for Research in Neurosciences and Neuropsychiatry, Rouffach, France. Jose.HabaRubio@hcuge.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology* Brain Diseases / diagnosis*, genetics* Caudate Nucleus / pathology Female Ferritins / metabolism Globus Pallidus / pathology Hemochromatosis / diagnosis*, genetics* Histocompatibility Antigens Class I / genetics Humans Image Processing, Computer-Assisted Iron / metabolism* Magnetic Resonance Imaging* Male Membrane Proteins / genetics Middle Aged Polysomnography Putamen / pathology Red Nucleus / pathology Reference Values Restless Legs Syndrome / diagnosis*, genetics* Substantia Nigra / pathology |
| Chemical | |
Reg. No./Substance:
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0/HFE protein, human; 0/Histocompatibility Antigens Class I; 0/Membrane Proteins; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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