Document Detail

Restless legs syndrome in patients with irritable bowel syndrome: response to small intestinal bacterial overgrowth therapy.
MedLine Citation:
PMID:  17934858     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) occurs in irritable bowel syndrome (IBS) and fibromyalgia. Since restless legs syndrome (RLS) occurs with fibromyalgia, a link between IBS, SIBO, and RLS was studied. METHODS: BS patients with abnormal lactulose breath tests received rifaximin 1,200 mg day(-1) for 10 days, followed by tegaserod 3 mg, long-term, and 1 month of zinc 220 mg day(-1) and once-daily probiotic (N = 11) or rifaximin monotherapy (N = 2). IBS symptom improvement was assessed after rifaximin. RLS symptoms, IBS symptoms, and overall IBS global improvement were assessed at last posttreatment visit: 8/10 patients were followed long-term (mean, 139 days; range, 54-450 days). RESULTS: Ten of 13 patients exhibited > or =80% improvement from baseline in RLS symptoms. Five maintained complete resolution of RLS symptoms. Global gastrointestinal symptom improvement was great (n = 6), moderate (n = 5), or mild (n = 2). CONCLUSION: This study suggests that SIBO associated with IBS may be a factor in some RLS patients and SIBO therapy provides long-term RLS improvement.
Leonard B Weinstock; Steve E Fern; Stephen P Duntley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-13
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1252-6     Citation Subset:  AIM; IM    
Washington University School of Medicine, St Louis, MO 63141, USA,
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MeSH Terms
Breath Tests
Drug Therapy, Combination
Gastrointestinal Agents / therapeutic use
Indoles / therapeutic use
Intestine, Small / microbiology*
Irritable Bowel Syndrome / complications*,  drug therapy,  microbiology*
Middle Aged
Pilot Projects
Restless Legs Syndrome / complications*
Rifamycins / therapeutic use
Serotonin Agonists
Treatment Outcome
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Indoles; 0/Rifamycins; 0/Serotonin Agonists; 145158-71-0/tegaserod; 88747-56-2/rifaximin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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