Document Detail

Restless legs syndrome in hemodialysis patients: association with calcium antagonists. A preliminary report.
MedLine Citation:
PMID:  17622723     Owner:  NLM     Status:  MEDLINE    
Uremia-related restless legs syndrome (RLS) is a known form of secondary RLS. This cross-sectional survey included patients (n = 82) on stable hemodialysis (HD; >3 months, Kt/V >1.2) who were iron-replete, free of neurodegenerative or psychiatric disorders, severe polyneuropathy and radiculopathy, not exposed to antipsychotics/antidepressants, and not severely anemic. Forty-nine (60%) were RLS 'positive', and 25 (31%) had severe/very severe symptoms (International Restless Legs Syndrome Study Group criteria). None had been diagnosed previously. In a multivariate analysis, the prevalence of RLS was higher in diabetic patients [vs. nondiabetics; prevalence ratio (PR) 2.32, 95% CI 1.50-3.60, p < 0.001] and those exposed to Ca2+ antagonists (vs. nonexposed; PR 2.02, CI 1.47-2.76, p < 0.001), and also increased with dialysis duration (PR 1.05, 95% CI 1.02-1.09, p < 0.001). Association of Ca2+ antagonists and RLS in uremic patients has not been reported previously and deserves further research.
Srdana Telarović; Maja Relja; Vladimir Trkulja
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-06-29
Journal Detail:
Title:  European neurology     Volume:  58     ISSN:  1421-9913     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  166-9     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Department of Neurology, Clinical Hospital Center Zagreb, Zagreb University School of Medicine, Zagreb, Croatia.
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MeSH Terms
Amlodipine / therapeutic use*
Calcium Channel Blockers / therapeutic use*
Cross-Sectional Studies
Logistic Models
Middle Aged
Nifedipine / therapeutic use*
Odds Ratio
Renal Dialysis*
Restless Legs Syndrome / drug therapy*,  epidemiology*
Retrospective Studies
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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