| Restless legs syndrome in hemodialysis patients: association with calcium antagonists. A preliminary report. | |
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MedLine Citation:
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PMID: 17622723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uremia-related restless legs syndrome (RLS) is a known form of secondary RLS. This cross-sectional survey included patients (n = 82) on stable hemodialysis (HD; >3 months, Kt/V >1.2) who were iron-replete, free of neurodegenerative or psychiatric disorders, severe polyneuropathy and radiculopathy, not exposed to antipsychotics/antidepressants, and not severely anemic. Forty-nine (60%) were RLS 'positive', and 25 (31%) had severe/very severe symptoms (International Restless Legs Syndrome Study Group criteria). None had been diagnosed previously. In a multivariate analysis, the prevalence of RLS was higher in diabetic patients [vs. nondiabetics; prevalence ratio (PR) 2.32, 95% CI 1.50-3.60, p < 0.001] and those exposed to Ca2+ antagonists (vs. nonexposed; PR 2.02, CI 1.47-2.76, p < 0.001), and also increased with dialysis duration (PR 1.05, 95% CI 1.02-1.09, p < 0.001). Association of Ca2+ antagonists and RLS in uremic patients has not been reported previously and deserves further research. |
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Authors:
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Srdana Telarović; Maja Relja; Vladimir Trkulja |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2007-06-29 |
Journal Detail:
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Title: European neurology Volume: 58 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-10-15 Completed Date: 2007-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 166-9 Citation Subset: IM |
Copyright Information:
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2007 S. Karger AG, Basel |
Affiliation:
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Department of Neurology, Clinical Hospital Center Zagreb, Zagreb University School of Medicine, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amlodipine / therapeutic use* Calcium Channel Blockers / therapeutic use* Cross-Sectional Studies Female Humans Logistic Models Male Middle Aged Nifedipine / therapeutic use* Odds Ratio Renal Dialysis* Restless Legs Syndrome / drug therapy*, epidemiology* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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