Document Detail

Restless legs syndrome in Parkinson's disease.
MedLine Citation:
PMID:  19691124     Owner:  NLM     Status:  MEDLINE    
We aimed to investigate the prevalence of restless legs syndrome (RLS) according to essential diagnostic criteria, and to explore potential associations with clinical features, especially motor fluctuations, in a cohort of 113 patients with idiopathic Parkinson's disease (PD). Twenty-eight (24%) fulfilled essential diagnostic criteria for RLS. They were younger (63.1 +/- 8.6 vs. 68.8 +/- 9.0 years; P = 0.004), had an earlier onset of PD (54.1 +/- 9.5 vs. 59.2 +/- 10.3 years; P = 0.018), and received lower levodopa equivalent doses (578.4 +/- 382.2 vs. 779.1 +/- 459.6 mg/day; P = 0.04) than patients with PD who scored negative for RLS. In 23 patients (82%), RLS symptom onset was after PD onset (mean interval, 4.5 +/- 3.7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD.
Cecilia M Peralta; Birgit Frauscher; Klaus Seppi; Elisabeth Wolf; Gregor K Wenning; Birgit Högl; Werner Poewe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-01-12     Revised Date:  2010-07-30    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2076-80     Citation Subset:  IM    
Copyright Information:
(c) 2009 Movement Disorder Society.
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
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MeSH Terms
Age Factors
Antiparkinson Agents / therapeutic use
Cohort Studies
Cross-Sectional Studies
Dopamine Agents / therapeutic use
Middle Aged
Movement / physiology
Parkinson Disease / complications*,  drug therapy,  epidemiology
Restless Legs Syndrome / epidemiology,  etiology*
Reg. No./Substance:
0/Antiparkinson Agents; 0/Dopamine Agents
Comment In:
Mov Disord. 2010 Jul 15;25(9):1314; author reply 1314-5   [PMID:  20593424 ]

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