| Restless leg syndrome associated with olanzapine: a case series. | |
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MedLine Citation:
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PMID: 20406161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Restless leg syndrome (RLS) is a common disorder associated with significant distress. We report three cases of drug induced RLS caused by olanzapine. In each case, RLS commenced after initiation of treatment with olanzapine and resolved after ceasing olanzapine. All three patients were subsequently treated with other atypical antipsychotics, risperidone, quetiapine or aripiprazole, without re-emergence of RLS. RLS is associated with central dopaminergic dysfunction. Dopamine agonists and L-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness related agitation might help in reducing the distress associated with it and improving patient compliance. |
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Authors:
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Shilpa Aggarwal; Seetald Dodd; Michael Berk |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Current drug safety Volume: 5 ISSN: 1574-8863 ISO Abbreviation: Curr Drug Saf Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101270895 Medline TA: Curr Drug Saf Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 129-31 Citation Subset: IM |
Affiliation:
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Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Victoria, Australia. shilpazq@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / adverse effects, therapeutic use Benzodiazepines / adverse effects* Dopamine Agents / therapeutic use Female Humans Male Middle Aged Restless Legs Syndrome / chemically induced*, diagnosis*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Dopamine Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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