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Resting respiratory variables and exercise capacity in adult patients with cystic fibrosis.
MedLine Citation:
PMID:  20594816     Owner:  NLM     Status:  In-Process    
INTRODUCTION: Cystic fibrosis (CF) is the most common life-limiting, recessively inherited disease in the white population, associated with significantly high morbidity and mortality rates; CF pulmonary disease, assessed by pulmonary function tests, arterial blood gases and the Schwachman score, remains the most prevalent in terms of morbidity in the adult CF population.
OBJECTIVES: The aim of the present study was to evaluate the relationship between resting respiratory variables and exercise capacity in adult patients with CF.
RESULTS: Study investigations undertaken in 18 CF patients and 11 healthy volunteers showed that among the resting lung function parameters, inspiratory capacity (IC) at rest was the only significant predictor of VO(2) peak (r=0.67, p<0.007) and VO(2)/t-slope (r=0.86, p<0.0001). The percentage of predicted FEV(1) in adult CF patients was 77+/-33% pred. vs 104+/-16% pred. in healthy subjects (p<0.006); the corresponding percentage of IC at rest was 82+/-36% pred. in patients vs 116+/-20% pred. in healthy (p<0.003). CF patients presented with a significantly prolonged rapid breathing after exercise (32br per minute at recovery for CF vs 22 for healthy; p<0.001), as well as a shortened inspiratory time.
CONCLUSION: Adult patients with CF show a limited exercise capacity with lower peak oxygen consumption and prolonged oxygen kinetics. Interestingly, decreased IC qualified as the only significant predictor of exercise capacity in our study.
G Perpati; S Nanas; E Pouliou; V Dionyssopoulou; E Stefanatou; E Armeniakou; A Papamichalopoulos; Ch Roussos
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Publication Detail:
Type:  Journal Article     Date:  2010-07-01
Journal Detail:
Title:  Respiratory medicine     Volume:  104     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1444-9     Citation Subset:  IM    
Cystic Fibrosis Outpatient Clinic, Athens Chest Hospital, Mesogion 152, Athens, Greece.
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