| Resting respiratory variables and exercise capacity in adult patients with cystic fibrosis. | |
| | |
MedLine Citation:
|
PMID: 20594816 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
INTRODUCTION: Cystic fibrosis (CF) is the most common life-limiting, recessively inherited disease in the white population, associated with significantly high morbidity and mortality rates; CF pulmonary disease, assessed by pulmonary function tests, arterial blood gases and the Schwachman score, remains the most prevalent in terms of morbidity in the adult CF population. OBJECTIVES: The aim of the present study was to evaluate the relationship between resting respiratory variables and exercise capacity in adult patients with CF. RESULTS: Study investigations undertaken in 18 CF patients and 11 healthy volunteers showed that among the resting lung function parameters, inspiratory capacity (IC) at rest was the only significant predictor of VO(2) peak (r=0.67, p<0.007) and VO(2)/t-slope (r=0.86, p<0.0001). The percentage of predicted FEV(1) in adult CF patients was 77+/-33% pred. vs 104+/-16% pred. in healthy subjects (p<0.006); the corresponding percentage of IC at rest was 82+/-36% pred. in patients vs 116+/-20% pred. in healthy (p<0.003). CF patients presented with a significantly prolonged rapid breathing after exercise (32br per minute at recovery for CF vs 22 for healthy; p<0.001), as well as a shortened inspiratory time. CONCLUSION: Adult patients with CF show a limited exercise capacity with lower peak oxygen consumption and prolonged oxygen kinetics. Interestingly, decreased IC qualified as the only significant predictor of exercise capacity in our study. |
| | |
Authors:
|
G Perpati; S Nanas; E Pouliou; V Dionyssopoulou; E Stefanatou; E Armeniakou; A Papamichalopoulos; Ch Roussos |
Related Documents
:
|
19145106 - Cardiopulmonary exercise testing in the functional and prognostic evaluation of patient... 8443946 - Cardiopulmonary exercise testing in patients with chronic obstructive pulmonary disease. 11802466 - Functional evaluation in patients with chronic obstructive pulmonary disease: pulmonary... 529086 - The effects of sudden airway hypercapnia on the initiation of exercise hyperpnoea in man. 16924526 - Isometric handgrip training improves local flow-mediated dilation in medicated hyperten... 7503006 - Comparison of effects on peak oxygen consumption, quality of life, and neurohormones of... |
Publication Detail:
|
Type: Journal Article Date: 2010-07-01 |
Journal Detail:
|
Title: Respiratory medicine Volume: 104 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
|
Languages: eng Pagination: 1444-9 Citation Subset: IM |
Affiliation:
|
Cystic Fibrosis Outpatient Clinic, Athens Chest Hospital, Mesogion 152, Athens, Greece. georgiaperpati@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Host response to influenza virus: protection versus immunopathology.
Next Document: Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia.