Document Detail

Resting pulse rates in a glaucoma clinic: the effect of topical and systemic beta-blocker usage.
MedLine Citation:
PMID:  15803169     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Beta-blockers have, for 25 years, been a commonly used agent in the treatment of raised intraocular pressure (IOP). Beta-blockers can also reduce the pulse rate. With no available literature examining a cohort of patients, this study aims to investigate the resting pulse rates in patients attending a specialist glaucoma clinic in order to identify if routine review of ophthalmic medication use is indicated. METHOD: The resting pulse rates of patients attending a glaucoma clinic were measured using pulseoximetry, with a medical and drug history established for each patient. RESULTS: In all, 205 patients were included in the study. A total of 101 (49%) of patients were using beta-blockers in some form. The mean pulse rate for patients not using beta-blockers (104 patients) was 76 beats per minute (bpm), for topical use only (68 patients) it was 70.3 bpm, for oral use (18 patients) it was 64.7 bpm, and 58 bpm for patients using both topical and oral beta-blockers (15 patients). Groups using beta-blockers (oral, topical, oral and topical) were considered in relation to patients not using beta-blockers. All groups using beta-blockers showed a significant association with causing a bradycardia of less than 60 bpm. Patients with a pulse rate of less than 50 bpm were significantly more likely to be using topical and oral beta-blockers than oral beta-blockers alone (P=0.01). CONCLUSION: Topical beta-blockers should be used with caution, even in the presence of established systemic beta-blocker use. Routine pulse rate monitoring and review of ophthalmic medication are indicated in patients using beta-blocker therapy.
C Tattersall; S Vernon; R Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eye (London, England)     Volume:  20     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-08-24     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Department of Ophthalmology, Queens Medical Centre, NHS trust, Nottingham, UK.
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MeSH Terms
Administration, Oral
Administration, Topical
Adrenergic beta-Antagonists / administration & dosage,  adverse effects*
Aged, 80 and over
Antihypertensive Agents / administration & dosage,  adverse effects*
Bradycardia / chemically induced
Drug Monitoring / methods
Drug Therapy, Combination
Glaucoma / drug therapy*,  physiopathology
Heart Rate / drug effects*
Middle Aged
Monitoring, Physiologic / methods
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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