Document Detail

Resting muscle sympathetic nerve activity does not predict duration of symptom-limited submaximal exercise in young patients with dilated cardiomyopathy.
MedLine Citation:
PMID:  9627525     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether increased sympathetic vasoconstrictor drive to the calf in heart failure is associated with reduced symptom-limited submaximal exercise performance. DESIGN: Blood pressure, heart rate and peroneal muscle sympathetic nerve activity (MSNA) were recorded during rest and before symptom-limited treadmill exercise at 70% of resting heart rate reserve for up to 45 mins. PATIENTS: Thirteen young patients with dilated cardiomyopathy (age 36 +/- 2 years). RESULTS: MSNA (45 +/- 6 bursts/min) was more than double the level documented in an age-, sex- and weight-matched group of normal subjects studied under identical baseline conditions. Patients with ventricular dysfunction exercised for 30 +/- 3 mins on average, but exercise distance and duration were independent of resting MSNA. CONCLUSIONS: In young patients with dilated cardiomyopathy, sympathetic nerve traffic to the calf vascular bed, measured at rest, does not predict the distance or duration of symptom-limited submaximal treadmill exercise.
K Hara; J S Floras
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  14     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-26     Completed Date:  1998-06-26     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  689-94     Citation Subset:  IM; S    
Division of Cardiology, Toronto Hospital, Ontario.
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MeSH Terms
Blood Pressure
Cardiomyopathy, Dilated / metabolism,  physiopathology*,  ultrasonography
Exercise / physiology*
Exercise Test
Follow-Up Studies
Heart Rate
Leg / innervation,  physiology
Middle Aged
Muscle, Skeletal / innervation*
Oxygen Consumption
Predictive Value of Tests
Rest / physiology*
Sympathetic Nervous System / physiopathology*
Vasoconstriction / physiology
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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