| Resting muscle sympathetic nerve activity does not predict duration of symptom-limited submaximal exercise in young patients with dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 9627525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether increased sympathetic vasoconstrictor drive to the calf in heart failure is associated with reduced symptom-limited submaximal exercise performance. DESIGN: Blood pressure, heart rate and peroneal muscle sympathetic nerve activity (MSNA) were recorded during rest and before symptom-limited treadmill exercise at 70% of resting heart rate reserve for up to 45 mins. PATIENTS: Thirteen young patients with dilated cardiomyopathy (age 36 +/- 2 years). RESULTS: MSNA (45 +/- 6 bursts/min) was more than double the level documented in an age-, sex- and weight-matched group of normal subjects studied under identical baseline conditions. Patients with ventricular dysfunction exercised for 30 +/- 3 mins on average, but exercise distance and duration were independent of resting MSNA. CONCLUSIONS: In young patients with dilated cardiomyopathy, sympathetic nerve traffic to the calf vascular bed, measured at rest, does not predict the distance or duration of symptom-limited submaximal treadmill exercise. |
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Authors:
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K Hara; J S Floras |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 14 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-26 Completed Date: 1998-06-26 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 689-94 Citation Subset: IM; S |
Affiliation:
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Division of Cardiology, Toronto Hospital, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Cardiomyopathy, Dilated / metabolism, physiopathology*, ultrasonography Echocardiography Electrocardiography Exercise / physiology* Exercise Test Female Follow-Up Studies Heart Rate Humans Leg / innervation, physiology Male Middle Aged Muscle, Skeletal / innervation* Oxygen Consumption Plethysmography Predictive Value of Tests Rest / physiology* Sympathetic Nervous System / physiopathology* Vasoconstriction / physiology Ventricular Function, Left / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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