| Resting heart rate and risk of type 2 diabetes in women. | |
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MedLine Citation:
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PMID: 20448009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Resting heart rate has been shown to predict risk of cardiovascular disease; its association with diabetes remains unclear, particularly in non-Western populations. METHODS: We evaluated the association between resting heart rate and risk of type 2 diabetes in the Shanghai Women's Health Study, a population-based prospective cohort study. The analysis included 47 571 Chinese women with no prior history of diabetes, cancer, cardiovascular disease or thyroid dysfunction at the time when resting heart rate was measured. Incident diabetes was ascertained through biennial in-person interviews. RESULTS: During a mean follow-up of 4.9 years, 849 women developed type 2 diabetes. For heart rate categories of < or =68, 69-72, 73-76, 77-80 and >80 beats/min, the incidence rates of diabetes per 1000 person-years were 2.91, 3.31, 3.71, 4.16 and 5.34, respectively. The multivariable-adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] for diabetes across increasing heart rate categories were 1, 1.21 (0.99-1.47), 1.30 (1.05-1.62), 1.37 (1.12-1.69) and 1.60 (1.28-2.00), respectively. Further analyses of the joint effects of heart rate with body mass index (BMI), waist-hip ratio (WHR) and blood pressure (BP) showed increased risk of diabetes with increasing heart rate in all categories of BMI, WHR or BP. The combinations of the highest heart rate category with highest BMI, WHR or BP category were associated with the highest HRs, ranging from 4.81 to 6.34. CONCLUSIONS: A high resting heart rate is independently associated with an increased risk of type 2 diabetes in women. The combinations of high heart rate with high BMI, WHR or BP level are associated with a substantially increased risk. |
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Authors:
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Xianglan Zhang; Xiao-Ou Shu; Yong-Bing Xiang; Gong Yang; Honglan Li; Hui Cai; Yu-Tang Gao; Wei Zheng |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-06 |
Journal Detail:
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Title: International journal of epidemiology Volume: 39 ISSN: 1464-3685 ISO Abbreviation: Int J Epidemiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7802871 Medline TA: Int J Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 900-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA. xianglan.zhang@vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Asian Continental Ancestry Group Blood Pressure Body Mass Index China / epidemiology Diabetes Mellitus, Type 2 / epidemiology*, physiopathology* Female Heart Rate* Humans Middle Aged Prospective Studies Risk Factors Waist-Hip Ratio |
| Grant Support | |
ID/Acronym/Agency:
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2K12HD043483-06/HD/NICHD NIH HHS; R01CA70867/CA/NCI NIH HHS; R01HL079123/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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