Document Detail

Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy.
MedLine Citation:
PMID:  19207479     Owner:  NLM     Status:  MEDLINE    
We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.
Andrea Mignatti; Daniel B Sims; Paolo C Colombo; Luis I Garcia; Rachel Bijou; Mario C Deng; Ulrich P Jorde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  27     ISSN:  1755-5914     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-03-26     Revised Date:  2009-08-19    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  42-8     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Biological Markers / blood
Chronic Disease
Exercise Test
Exercise Tolerance / drug effects*
Heart Failure / drug therapy*,  metabolism,  physiopathology
Heart Rate / drug effects*
Middle Aged
Norepinephrine / blood
Practice Guidelines as Topic
Receptors, Adrenergic, beta-1 / antagonists & inhibitors*
Treatment Outcome
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Biological Markers; 0/Receptors, Adrenergic, beta-1; 51-41-2/Norepinephrine
Comment In:
Cardiovasc Ther. 2009 Fall;27(3):221   [PMID:  19689621 ]

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